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Heritability and Genome-Wide Association Analyses of Sleep Duration in Children: The EAGLE Consortium.
Marinelli, Marcella; Pappa, Irene; Bustamante, Mariona; Bonilla, Carolina; Suarez, Anna; Tiesler, Carla M; Vilor-Tejedor, Natalia; Zafarmand, Mohammad Hadi; Alvarez-Pedrerol, Mar; Andersson, Sture; Bakermans-Kranenburg, Marian J; Estivill, Xavier; Evans, David M; Flexeder, Claudia; Forns, Joan; Gonzalez, Juan R; Guxens, Monica; Huss, Anke; van IJzendoorn, Marinus H; Jaddoe, Vincent W V; Julvez, Jordi; Lahti, Jari; López-Vicente, Mónica; Lopez-Espinosa, Maria-Jose; Manz, Judith; Mileva-Seitz, Viara R; Perola, Markus; Pesonen, Anu-Katriina; Rivadeneira, Fernando; Salo, Perttu P; Shahand, Shayan; Schulz, Holger; Standl, Marie; Thiering, Elisabeth; Timpson, Nicholas J; Torrent, Maties; Uitterlinden, André G; Smith, George Davey; Estarlich, Marisa; Heinrich, Joachim; Räikkönen, Katri; Vrijkotte, Tanja G M; Tiemeier, Henning; Sunyer, Jordi.
Afiliação
  • Marinelli M; Agency for Healthcare Quality and Evaluation of Catalonia (AQuAS), Roc Boronat, Barcelona, Spain.
  • Pappa I; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.
  • Bustamante M; ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
  • Bonilla C; School of Pedagogical and Educational Sciences, Erasmus University Rotterdam, The Netherlands.
  • Suarez A; Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Tiesler CM; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.
  • Vilor-Tejedor N; ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
  • Zafarmand MH; Centre for Genomic Regulation (CRG), the Barcelona Institute of Science and Technology, Barcelona, Spain.
  • Alvarez-Pedrerol M; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
  • Andersson S; School of Social and Community Medicine, University of Bristol, Bristol, UK.
  • Bakermans-Kranenburg MJ; MRC/University of Bristol Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
  • Estivill X; Institute of behavioural sciences, University of Helsinki, Helsinki, Finland.
  • Evans DM; Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
  • Flexeder C; Ludwig-Maximilians-University of Munich, Dr. von Hauner Children's Hospital, Division of Metabolic Diseases and Nutritional Medicine, Munich, Germany.
  • Forns J; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.
  • Gonzalez JR; ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
  • Guxens M; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
  • Huss A; Department of Public Health, Academic Medical Center (AMC), University of Amsterdam, The Netherlands.
  • van IJzendoorn MH; Department of Obstetrics and Gynaecology, Academic Medical Centre, University of Amsterdam, The Netherlands.
  • Jaddoe VW; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.
  • Julvez J; ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
  • Lahti J; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
  • López-Vicente M; Children's Hospital, University of Helsinki, and Helsinki University Hospital, Helsinki, Finland.
  • Lopez-Espinosa MJ; Centre for Child and Family Studies, Leiden University, Leiden, The Netherlands.
  • Manz J; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.
  • Mileva-Seitz VR; Centre for Genomic Regulation (CRG), the Barcelona Institute of Science and Technology, Barcelona, Spain.
  • Perola M; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
  • Pesonen AK; Institut Hospital del Mar d'Investigacions Mediques (IMIM), 08003 Barcelona, Spain.
  • Rivadeneira F; School of Social and Community Medicine, University of Bristol, Bristol, UK.
  • Salo PP; MRC/University of Bristol Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
  • Shahand S; University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia.
  • Schulz H; Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
  • Standl M; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.
  • Thiering E; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
  • Timpson NJ; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.
  • Torrent M; ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
  • Uitterlinden AG; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
  • Smith GD; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.
  • Estarlich M; ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
  • Heinrich J; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
  • Räikkönen K; Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, the Netherlands.
  • Vrijkotte TG; Institute for Risk Assessment Sciences, Utrecht University, the Netherlands.
  • Tiemeier H; School of Pedagogical and Educational Sciences, Erasmus University Rotterdam, The Netherlands.
  • Sunyer J; Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands.
Sleep ; 39(10): 1859-1869, 2016 Oct 01.
Article em En | MEDLINE | ID: mdl-27568811
STUDY OBJECTIVES: Low or excessive sleep duration has been associated with multiple outcomes, but the biology behind these associations remains elusive. Specifically, genetic studies in children are scarce. In this study, we aimed to: (1) estimate the proportion of genetic variance of sleep duration in children attributed to common single nucleotide polymorphisms (SNPs), (2) identify novel SNPs associated with sleep duration in children, and (3) investigate the genetic overlap of sleep duration in children and related metabolic and psychiatric traits. METHODS: We performed a population-based molecular genetic study, using data form the EArly Genetics and Life course Epidemiology (EAGLE) Consortium. 10,554 children of European ancestry were included in the discovery, and 1,250 children in the replication phase. RESULTS: We found evidence of significant but modest SNP heritability of sleep duration in children (SNP h2 0.14, 95% CI [0.05, 0.23]) using the LD score regression method. A novel region at chromosome 11q13.4 (top SNP: rs74506765, P = 2.27e-08) was associated with sleep duration in children, but this was not replicated in independent studies. Nominally significant genetic overlap was only found (rG = 0.23, P = 0.05) between sleep duration in children and type 2 diabetes in adults, supporting the hypothesis of a common pathogenic mechanism. CONCLUSIONS: The significant SNP heritability of sleep duration in children and the suggestive genetic overlap with type 2 diabetes support the search for genetic mechanisms linking sleep duration in children to multiple outcomes in health and disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sono / Característica Quantitativa Herdável / Polimorfismo de Nucleotídeo Único / Estudo de Associação Genômica Ampla Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Sleep Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sono / Característica Quantitativa Herdável / Polimorfismo de Nucleotídeo Único / Estudo de Associação Genômica Ampla Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Sleep Ano de publicação: 2016 Tipo de documento: Article