Effect of inhibition of protein synthesis on cholestasis induced by taurolithocholate, lithocholate, and a manganese-bilirubin combination in the rat.
Biochem Pharmacol
; 38(15): 2543-9, 1989 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-2757652
ABSTRACT
Taurolithocholate, lithocholate, and a manganese-bilirubin combination produced a rapid reduction in bile flow after i.v. injection in the rat. The effect was diminished or blocked completely by pretreating the animals with cycloheximide or ethionine, known inhibitors of protein synthesis. The injection sequence and time period between administration of the inhibitor of protein synthesis and the cholestatic agent influenced the degree to which they modulated the cholestatic effect. The results indicate that uninterrupted protein synthesis is required for the expression of maximal reduction of bile flow by taurolithocholate, lithocholate, and a manganese-bilirubin combination.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Taurolitocólico
/
Bilirrubina
/
Inibidores da Síntese de Proteínas
/
Colestase
/
Ácido Litocólico
/
Manganês
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Biochem Pharmacol
Ano de publicação:
1989
Tipo de documento:
Article