LC-MS Supported Studies on the in Vitro Metabolism of both Enantiomers of Flubatine and the in Vivo Metabolism of (+)-[(18)F]Flubatine-A Positron Emission Tomography Radioligand for Imaging &#945;4ß2 Nicotinic Acetylcholine Receptors.

Ludwig, Friedrich-Alexander; Smits, René; Fischer, Steffen; Donat, Cornelius K; Hoepping, Alexander; Brust, Peter; Steinbach, Jörg

LC-MS Supported Studies on the in Vitro Metabolism of both Enantiomers of Flubatine and the in Vivo Metabolism of (+)-[(18)F]Flubatine-A Positron Emission Tomography Radioligand for Imaging α4ß2 Nicotinic Acetylcholine Receptors.

Ludwig, Friedrich-Alexander; Smits, René; Fischer, Steffen; Donat, Cornelius K; Hoepping, Alexander; Brust, Peter; Steinbach, Jörg.

Afiliação

Ludwig FA; Helmholtz-Zentrum Dresden-Rossendorf, Research Site Leipzig, Institute of Radiopharmaceutical Cancer Research, Permoserstraße 15, Leipzig 04318, Germany. f.ludwig@hzdr.de.
Smits R; ABX Advanced Biochemical Compounds GmbH, Heinrich-Gläser-Straße 10-14, Radeberg 01454, Germany. smits@abx.de.
Fischer S; Helmholtz-Zentrum Dresden-Rossendorf, Research Site Leipzig, Institute of Radiopharmaceutical Cancer Research, Permoserstraße 15, Leipzig 04318, Germany. s.fischer@hzdr.de.
Donat CK; Division of Brain Sciences, Imperial College London, Du Cane Road, London W12 0NN, UK. c.donat@imperial.ac.uk.
Hoepping A; ABX Advanced Biochemical Compounds GmbH, Heinrich-Gläser-Straße 10-14, Radeberg 01454, Germany. hoepping@abx.de.
Brust P; Helmholtz-Zentrum Dresden-Rossendorf, Research Site Leipzig, Institute of Radiopharmaceutical Cancer Research, Permoserstraße 15, Leipzig 04318, Germany. p.brust@hzdr.de.
Steinbach J; Helmholtz-Zentrum Dresden-Rossendorf, Research Site Leipzig, Institute of Radiopharmaceutical Cancer Research, Permoserstraße 15, Leipzig 04318, Germany. j.steinbach@hzdr.de.

Molecules ; 21(9)2016 Sep 08.

Article em En | MEDLINE | ID: mdl-27617996

Assuntos

Benzamidas; Compostos Bicíclicos Heterocíclicos com Pontes; Microssomos Hepáticos/metabolismo; Tomografia por Emissão de Pósitrons; Compostos Radiofarmacêuticos; Receptores Nicotínicos/metabolismo; Animais; Benzamidas/química; Benzamidas/farmacocinética; Benzamidas/farmacologia; Compostos Bicíclicos Heterocíclicos com Pontes/química; Compostos Bicíclicos Heterocíclicos com Pontes/farmacocinética; Compostos Bicíclicos Heterocíclicos com Pontes/farmacologia; Cromatografia Líquida; Feminino; Humanos; Espectrometria de Massas; Camundongos; Compostos Radiofarmacêuticos/química; Compostos Radiofarmacêuticos/farmacocinética; Compostos Radiofarmacêuticos/farmacologia

Palavras-chave

NCFHEB; epibatidine; flubatine; liquid chromatography-mass spectrometry (LC-MS); liver microsomes; nicotinic acetylcholine receptors (nAChRs); positron emission tomography (PET); radiometabolites

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzamidas / Microssomos Hepáticos / Receptores Nicotínicos / Compostos Bicíclicos Heterocíclicos com Pontes / Compostos Radiofarmacêuticos / Tomografia por Emissão de Pósitrons Limite: Animals / Female / Humans Idioma: En Revista: Molecules Ano de publicação: 2016 Tipo de documento: Article

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