Anti-Ebola Activity of Diazachrysene Small Molecules.
ACS Infect Dis
; 1(6): 264-71, 2015 Jun 12.
Article
em En
| MEDLINE
| ID: mdl-27622742
ABSTRACT
Herein we report on a diazachrysene class of small molecules that exhibit potent antiviral activity against the Ebola (EBOV) virus. The antiviral compounds are easily synthesized, and the most active compounds have excellent in vitro activity (0.34-0.70 µM) and are significantly less lipophilic than their predecessors. The three most potent diazachrysene antivirals do not exhibit any toxicity in vivo and protected 70-90% of the mice at 10 mg/kg following EBOV challenge. Together, these studies suggest that diazachrysenes are a promising class of compounds for hit to lead optimization and as potential Ebola therapeutics.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
ACS Infect Dis
Ano de publicação:
2015
Tipo de documento:
Article