Carbon extension in peptidylnucleoside biosynthesis by radical SAM enzymes.
Nat Chem Biol
; 12(11): 905-907, 2016 Nov.
Article
em En
| MEDLINE
| ID: mdl-27642865
ABSTRACT
Nikkomycins and polyoxins are antifungal peptidylnucleoside antibiotics active against human and plant pathogens. Here we report that during peptidylnucleoside biosynthesis in Streptomyces cacaoi and S. tendae, the C5' extension of the nucleoside essential for downstream structural diversification is catalyzed by a conserved radical S-adenosyl-L-methionine (SAM) enzyme, PolH or NikJ. This is distinct from the nucleophilic mechanism reported for antibacterial nucleosides and represents a new mechanism of nucleoside natural product biosynthesis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Proteínas Metiltransferases
/
Carbono
/
Nucleosídeos
Idioma:
En
Revista:
Nat Chem Biol
Ano de publicação:
2016
Tipo de documento:
Article