Change of deformability and Heinz body formation in G6PD-deficient erythrocytes treated with 5-hydroxy-6-desmethylprimaquine.
Blood Cells
; 15(2): 443-52; discussion 453-4, 1989.
Article
em En
| MEDLINE
| ID: mdl-2765673
ABSTRACT
Glucose-6-phosphate deficient human erythrocytes were incubated with low concentrations of 5-hydroxy-6-desmethylprimaquine, a metabolite of primaquine in animals, for up to 18 hours under sterile conditions. These erythrocytes became less deformable than untreated erythrocytes. This decrease in deformability was closely associated with the extent and time course of formation of Heinz bodies in the G6PD-deficient erythrocytes. These results support the hypothesis that the in vivo formation of low concentrations of 5H6DPQ by metabolism of primaquine could be the cause of Heinz body formation and the hemolytic anemia seen when primaquine is administered to G6PD-deficient individuals.
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Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Primaquina
/
Deformação Eritrocítica
/
Deficiência de Glucosefosfato Desidrogenase
/
Corpos de Heinz
/
Antimaláricos
Limite:
Humans
Idioma:
En
Revista:
Blood Cells
Ano de publicação:
1989
Tipo de documento:
Article