Oriented collagen fibers direct tumor cell intravasation.
Proc Natl Acad Sci U S A
; 113(40): 11208-11213, 2016 10 04.
Article
em En
| MEDLINE
| ID: mdl-27663743
ABSTRACT
In this work, we constructed a Collagen I-Matrigel composite extracellular matrix (ECM). The composite ECM was used to determine the influence of the local collagen fiber orientation on the collective intravasation ability of tumor cells. We found that the local fiber alignment enhanced cell-ECM interactions. Specifically, metastatic MDA-MB-231 breast cancer cells followed the local fiber alignment direction during the intravasation into rigid Matrigel (â¼10 mg/mL protein concentration).
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Colágeno
/
Metástase Neoplásica
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Neoplasias
Limite:
Female
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Humans
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Ano de publicação:
2016
Tipo de documento:
Article