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Oriented collagen fibers direct tumor cell intravasation.
Han, Weijing; Chen, Shaohua; Yuan, Wei; Fan, Qihui; Tian, Jianxiang; Wang, Xiaochen; Chen, Longqing; Zhang, Xixiang; Wei, Weili; Liu, Ruchuan; Qu, Junle; Jiao, Yang; Austin, Robert H; Liu, Liyu.
Afiliação
  • Han W; Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China 100190.
  • Chen S; Materials Science and Engineering, Arizona State University, Tempe, AZ 85281.
  • Yuan W; Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen University, Shenzhen, China 518060.
  • Fan Q; Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China 100190.
  • Tian J; Materials Science and Engineering, Arizona State University, Tempe, AZ 85281.
  • Wang X; Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China 100190.
  • Chen L; Division of Physical Science and Engineering, King Abdullah University of Science & Technology, Thuwal, Saudi Arabia 23955-6900.
  • Zhang X; Innovative Drug Research Center, Chongqing University, Chongqing, China 401331.
  • Wei W; Innovative Drug Research Center, Chongqing University, Chongqing, China 401331.
  • Liu R; College of Physics, Chongqing University, Chongqing, China 401331.
  • Qu J; Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen University, Shenzhen, China 518060.
  • Jiao Y; Materials Science and Engineering, Arizona State University, Tempe, AZ 85281.
  • Austin RH; Department of Physics, Princeton University, Princeton, NJ 08544 Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen University, Shenzhen, China 518060; lyliu@cqu.edu.cn austin@princeton.edu.
  • Liu L; College of Physics, Chongqing University, Chongqing, China 401331; Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China 100190; lyliu@cqu.edu.cn austin@princeton.edu.
Proc Natl Acad Sci U S A ; 113(40): 11208-11213, 2016 10 04.
Article em En | MEDLINE | ID: mdl-27663743
ABSTRACT
In this work, we constructed a Collagen I-Matrigel composite extracellular matrix (ECM). The composite ECM was used to determine the influence of the local collagen fiber orientation on the collective intravasation ability of tumor cells. We found that the local fiber alignment enhanced cell-ECM interactions. Specifically, metastatic MDA-MB-231 breast cancer cells followed the local fiber alignment direction during the intravasation into rigid Matrigel (∼10 mg/mL protein concentration).
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colágeno / Metástase Neoplásica / Neoplasias Limite: Female / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colágeno / Metástase Neoplásica / Neoplasias Limite: Female / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2016 Tipo de documento: Article