Macrophage effector responses of horses are influenced by expression of CD154.
Vet Immunol Immunopathol
; 180: 40-44, 2016 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-27692094
ABSTRACT
Reactive intermediates contribute to innate immunity by providing phagocytes with a mechanism of defense against bacteria, viruses and parasites. To better characterize the role of CD154 in the production of reactive intermediates, we cloned and expressed recombinant equine CD154 (reqCD154) in Chinese Hamster Ovary (CHO). In co-culture experiments, CHO cells ectopically expressing reqCD154 elicited superoxide production in monocyte-derived macrophages (MDM). Collectively, our results indicate that regulation of CD154 expression plays a role in innate host defenses.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ligante de CD40
/
Cavalos
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Macrófagos
Limite:
Animals
Idioma:
En
Revista:
Vet Immunol Immunopathol
Ano de publicação:
2016
Tipo de documento:
Article