New lasiodiplodins from mangrove endophytic fungus Lasiodiplodia sp. 318.
Nat Prod Res
; 31(3): 326-332, 2017 Feb.
Article
em En
| MEDLINE
| ID: mdl-27696893
ABSTRACT
Two new lasiodiplodins (1-2) together with three known analogues, were isolated from a mangrove endophytic fungus, Lasiodiplodia sp. 318#. Their structures were established by spectroscopic techniques (1D- and 2D-NMR, HR-ESI-MS, etc.), and electronic circular dichroism. Cytotoxic activities of compounds 1-5 were evaluated in vitro. Compound 4 was the most potent, with IC50 values of 5.29 µM against MMQ, 13.05 µM against GH3. Preliminary structural-activity analysis indicated that the functional group (resorcinol-3-OH) contributed greatly to the binding of Lasiodiplodins to the cytotoxic activities.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ascomicetos
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Zearalenona
Limite:
Humans
Idioma:
En
Revista:
Nat Prod Res
Ano de publicação:
2017
Tipo de documento:
Article