Effects of Boron-Based Gel on Radiation-Induced Dermatitis in Breast Cancer: A Double-Blind, Placebo-Controlled Trial.
J Invest Surg
; 30(3): 187-192, 2017 Jun.
Article
em En
| MEDLINE
| ID: mdl-27700210
ABSTRACT
AIM:
This study is aimed to evaluate the effects of boron on radiation-induced skin reactions (RISR) in breast cancer patients. MATERIAL ANDMETHODS:
After 47 patients with invasive ductal carcinoma underwent radiotherapy, 23 (49%) received a boron-based gel, and 24 (51%) received placebo. Assessments were performed according to the Radiation Therapy Oncology Group (RTOG) skin scale and a Five-Point Horizontal Scale (FPHS).RESULTS:
At the end of the fifth week of radiotherapy, the RTOG scores in the boron group were significantly lower than those in the placebo group (p = .024). The FPHS score was higher in the placebo group than in the boron group, and this difference was not statistically significant (p = .079).CONCLUSION:
Using the RTOG scoring system, we revealed that the application of a boron-based gel diminished RISR. The mechanism of action is unclear but may be related to antioxidant, wound healing, and thermal degradation effects of boron.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
/
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Radiodermite
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Boro
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Neoplasias da Mama
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Carcinoma Ductal de Mama
Tipo de estudo:
Clinical_trials
Limite:
Adult
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Aged
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
J Invest Surg
Ano de publicação:
2017
Tipo de documento:
Article