Caspase-1 deficiency promotes high-fat diet-induced adipose tissue inflammation and the development of obesity.
Am J Physiol Endocrinol Metab
; 311(5): E881-E890, 2016 11 01.
Article
em En
| MEDLINE
| ID: mdl-27702746
ABSTRACT
Caspase-1 is a cysteine protease responsible for the processing of the proinflammatory cytokine interleukin-1ß and activated by the formation of inflammasome complexes. Although several investigations have found a link between diet-induced obesity and caspase-1, the relationship remains controversial. Here, we found that mice deficient in caspase-1 were susceptible to high-fat diet-induced obesity with increased adiposity as well as normal lipid and glucose metabolism. Caspase-1 deficiency clearly promoted the infiltration of inflammatory macrophages and increased the production of C-C motif chemokine ligand 2 (CCL2) in the adipose tissue. The dominant cellular source of CCL2 was stromal vascular fraction rather than adipocytes in the adipose tissue. These findings demonstrate a critical role of caspase-1 in macrophage-driven inflammation in the adipose tissue and the development of obesity. These data provide novel insights into the mechanisms underlying inflammation in the pathophysiology of obesity.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tecido Adiposo
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Quimiocina CCL2
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Caspase 1
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Macrófagos
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Obesidade
Limite:
Animals
Idioma:
En
Revista:
Am J Physiol Endocrinol Metab
Ano de publicação:
2016
Tipo de documento:
Article