Killing filarial nematode parasites: role of treatment options and host immune response.
Infect Dis Poverty
; 5(1): 86, 2016 Oct 03.
Article
em En
| MEDLINE
| ID: mdl-27716412
ABSTRACT
BACKGROUND:
There is compelling evidence that not only do anti-filarials significantly reduce larval forms, but that host immune responses also contribute to the clearance of filarial parasites; however, the underlying mechanisms have not been fully elucidated. MAIN TEXT Filarial infections caused by Wuchereria bancrofti and Brugia species (lymphatic filariasis) and Onchocerca volvulus (onchocerciasis) affect almost 200 million individuals worldwide and pose major public health challenges in endemic regions. Indeed, the collective disability-adjusted life years for both infections is 3.3 million. Infections with these thread-like nematodes are chronic and, although most individuals develop a regulated state, a portion develop severe forms of pathology. Mass drug administration (MDA) programmes on endemic populations focus on reducing prevalence of people with microfilariae, the worm's offspring in the blood, to less than 1 %. Although this has been successful in some areas, studies show that MDA will be required for longer than initially conceived.CONCLUSION:
This paper highlights the mode of action of the various antifilarial treatment strategies and role of host immune response.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Filariose
/
Filaricidas
/
Filarioidea
/
Imunidade Inata
Tipo de estudo:
Risk_factors_studies
Aspecto:
Patient_preference
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Infect Dis Poverty
Ano de publicação:
2016
Tipo de documento:
Article