Simultaneous analysis of 35 specific antihypertensive adulterants in dietary supplements using LC/MS/MS.
Biomed Chromatogr
; 31(4)2017 Apr.
Article
em En
| MEDLINE
| ID: mdl-27716982
ABSTRACT
A sensitive and specific LC/MS/MS method was developed for the simultaneous analysis of 35 compounds used for treating hypertension as adulterants in dietary supplements. The method was validated for specificity, linearity, accuracy, precision, limit of detection, limit of quantitation, stability and recovery. The limit of detection and limit of quantitation ranged from 0.20 to 20.0 and 0.50 to 60.0 ng/g, respectively. The linearity was good (r2 > 0.999), with intra- and interday precision levels of 0.43-7.87% and 0.65-9.95% and the intra- and interday accuracies of 84.36-115.82% and 83.78-118.69%, respectively. The stability (relative standard deviation) was <14.75%. The mean recovery was 80.81-117.86% (relative standard deviation <10.00%). Ninety-seven commercial dietary supplements available in South Korea were analyzed. While none contained detectable amounts of the 35 antihypertensive compounds, the developed LC/MS/MS procedure can be used for routine analysis to monitor illegal adulteration in various forms of dietary supplements.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Suplementos Nutricionais
/
Anti-Hipertensivos
Tipo de estudo:
Diagnostic_studies
País/Região como assunto:
Asia
Idioma:
En
Revista:
Biomed Chromatogr
Ano de publicação:
2017
Tipo de documento:
Article