Your browser doesn't support javascript.
loading
Stachybotrysin, an Osteoclast Differentiation Inhibitor from the Marine-Derived Fungus Stachybotrys sp. KCB13F013.
Kim, Jong Won; Ko, Sung-Kyun; Kim, Hye-Min; Kim, Gun-Hee; Son, Sangkeun; Kim, Gil Soo; Hwang, Gwi Ja; Jeon, Eun Soo; Shin, Kee-Sun; Ryoo, In-Ja; Hong, Young-Soo; Oh, Hyuncheol; Lee, Kyung Ho; Soung, Nak-Kyun; Hashizume, Daisuke; Nogawa, Toshihiko; Takahashi, Shunji; Kim, Bo Yeon; Osada, Hiroyuki; Jang, Jae-Hyuk; Ahn, Jong Seog.
Afiliação
  • Kim JW; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology , Cheongju, 28116, South Korea.
  • Ko SK; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology , Cheongju, 28116, South Korea.
  • Kim HM; Department of Biomolecular Science, University of Science and Technology , Daejeon 34113, South Korea.
  • Kim GH; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology , Cheongju, 28116, South Korea.
  • Son S; Department of Biomolecular Science, University of Science and Technology , Daejeon 34113, South Korea.
  • Kim GS; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology , Cheongju, 28116, South Korea.
  • Hwang GJ; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology , Cheongju, 28116, South Korea.
  • Jeon ES; Department of Biomolecular Science, University of Science and Technology , Daejeon 34113, South Korea.
  • Shin KS; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology , Cheongju, 28116, South Korea.
  • Ryoo IJ; Department of Biomolecular Science, University of Science and Technology , Daejeon 34113, South Korea.
  • Hong YS; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology , Cheongju, 28116, South Korea.
  • Oh H; Department of Biomolecular Science, University of Science and Technology , Daejeon 34113, South Korea.
  • Lee KH; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology , Cheongju, 28116, South Korea.
  • Soung NK; Industrial Bio-materials Research Center , Daejeon 34141, South Korea.
  • Hashizume D; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology , Cheongju, 28116, South Korea.
  • Nogawa T; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology , Cheongju, 28116, South Korea.
  • Takahashi S; Department of Biomolecular Science, University of Science and Technology , Daejeon 34113, South Korea.
  • Kim BY; College of Pharmacy, Wonkwang University , Iksan 54538, South Korea.
  • Osada H; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology , Cheongju, 28116, South Korea.
  • Jang JH; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology , Cheongju, 28116, South Korea.
  • Ahn JS; Department of Biomolecular Science, University of Science and Technology , Daejeon 34113, South Korea.
J Nat Prod ; 79(10): 2703-2708, 2016 10 28.
Article em En | MEDLINE | ID: mdl-27726391
ABSTRACT
Two new phenylspirodrimane derivatives, stachybotrysin (1) and stachybotrylactone B (2), were isolated from the cultures of the marine-derived fungus Stachybotrys sp. KCB13F013. The structures were determined by analyzing the spectroscopic data (1D and 2D NMR and MS) and chemical transformation, including the modified Mosher's method and single-crystal X-ray structure analysis. Compound 1 exhibited an inhibitory effect on osteoclast differentiation in bone marrow macrophage cells via suppressing the RANKL-induced activation of p-ERK, p-JNK, p-p38, c-Fos, and NFATc1.
Assuntos
Buscar no Google
Imprimir
XML
PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoclastos / Stachybotrys Limite: Animals Idioma: En Revista: J Nat Prod Ano de publicação: 2016 Tipo de documento: Article
Buscar no Google
Imprimir
XML
PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoclastos / Stachybotrys Limite: Animals Idioma: En Revista: J Nat Prod Ano de publicação: 2016 Tipo de documento: Article