Human whole genome genotype and transcriptome data for Alzheimer's and other neurodegenerative diseases.
Sci Data
; 3: 160089, 2016 Oct 11.
Article
em En
| MEDLINE
| ID: mdl-27727239
ABSTRACT
Previous genome-wide association studies (GWAS), conducted by our group and others, have identified loci that harbor risk variants for neurodegenerative diseases, including Alzheimer's disease (AD). Human disease variants are enriched for polymorphisms that affect gene expression, including some that are known to associate with expression changes in the brain. Postulating that many variants confer risk to neurodegenerative disease via transcriptional regulatory mechanisms, we have analyzed gene expression levels in the brain tissue of subjects with AD and related diseases. Herein, we describe our collective datasets comprised of GWAS data from 2,099 subjects; microarray gene expression data from 773 brain samples, 186 of which also have RNAseq; and an independent cohort of 556 brain samples with RNAseq. We expect that these datasets, which are available to all qualified researchers, will enable investigators to explore and identify transcriptional mechanisms contributing to neurodegenerative diseases.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Genoma Humano
/
Doenças Neurodegenerativas
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Doença de Alzheimer
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Transcriptoma
Limite:
Humans
Idioma:
En
Revista:
Sci Data
Ano de publicação:
2016
Tipo de documento:
Article