Phosphorylation of cofilin-1 by ERK confers HDAC inhibitor resistance in hepatocellular carcinoma cells via decreased ROS-mediated mitochondria injury.

Liao, P-H; Hsu, H-H; Chen, T-S; Chen, M-C; Day, C-H; Tu, C-C; Lin, Y-M; Tsai, F-J; Kuo, W-W; Huang, C-Y

Liao, P-H; Hsu, H-H; Chen, T-S; Chen, M-C; Day, C-H; Tu, C-C; Lin, Y-M; Tsai, F-J; Kuo, W-W; Huang, C-Y.

Afiliação

Liao PH; Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.
Hsu HH; Division of Colorectal Surgery, Mackay Memorial Hospital, Taipei, Taiwan.
Chen TS; Department of Mackay Medicine, Nursing and Management College, Taipei, Taiwan.
Chen MC; Biomaterials Translational Research Center, China Medical University Hospital, Taichung, Taiwan.
Day CH; Division of Colorectal Surgery, Taichung Veterans General Hospital, Taichung, Taiwan.
Tu CC; Department of Nursing, Mei Ho University, Pingtung, Taiwan.
Lin YM; Division of Chest Medicine, Department of Internal Medicine, Armed Force Taichung General Hospital, Taichung, Taiwan.
Tsai FJ; Department of Pathology, Changhua Christian Hospital, Changhua, Taiwan.
Kuo WW; Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan.
Huang CY; Department of Biological Science and Technology, China Medical University, Taichung, Taiwan.

Oncogene ; 36(14): 1978-1990, 2017 04 06.

Article em En | MEDLINE | ID: mdl-27748761

Assuntos

Carcinoma Hepatocelular/tratamento farmacológico; Cofilina 1/metabolismo; Resistencia a Medicamentos Antineoplásicos; Inibidores de Histona Desacetilases/uso terapêutico; Neoplasias Hepáticas/tratamento farmacológico; Mitocôndrias/efeitos dos fármacos; Espécies Reativas de Oxigênio/toxicidade; Animais; Carcinoma Hepatocelular/metabolismo; Carcinoma Hepatocelular/patologia; MAP Quinases Reguladas por Sinal Extracelular/metabolismo; Humanos; Neoplasias Hepáticas/metabolismo; Camundongos; Camundongos Nus; Mitocôndrias/metabolismo; Fosforilação; Espécies Reativas de Oxigênio/metabolismo; Transdução de Sinais/efeitos dos fármacos; Células Tumorais Cultivadas

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espécies Reativas de Oxigênio / Carcinoma Hepatocelular / Resistencia a Medicamentos Antineoplásicos / Cofilina 1 / Inibidores de Histona Desacetilases / Neoplasias Hepáticas / Mitocôndrias Limite: Animals / Humans Idioma: En Revista: Oncogene Ano de publicação: 2017 Tipo de documento: Article

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