Genetic and biochemical insights into the itaconate pathway of Ustilago maydis enable enhanced production.

Geiser, Elena; Przybilla, Sandra K; Engel, Meike; Kleineberg, Wiebke; Büttner, Linda; Sarikaya, Eda; Hartog, Tim den; Klankermayer, Jürgen; Leitner, Walter; Bölker, Michael; Blank, Lars M; Wierckx, Nick

Geiser, Elena; Przybilla, Sandra K; Engel, Meike; Kleineberg, Wiebke; Büttner, Linda; Sarikaya, Eda; Hartog, Tim den; Klankermayer, Jürgen; Leitner, Walter; Bölker, Michael; Blank, Lars M; Wierckx, Nick.

Afiliação

Geiser E; iAMB - Institute of Applied Microbiology, ABBt - Aachen Biology and Biotechnology, RWTH Aachen University, Worringerweg 1, D-52074 Aachen, Germany; BioSC, c/o Forschungszentrum Jülich, D-52425 Jülich, Germany.
Przybilla SK; iAMB - Institute of Applied Microbiology, ABBt - Aachen Biology and Biotechnology, RWTH Aachen University, Worringerweg 1, D-52074 Aachen, Germany.
Engel M; iAMB - Institute of Applied Microbiology, ABBt - Aachen Biology and Biotechnology, RWTH Aachen University, Worringerweg 1, D-52074 Aachen, Germany.
Kleineberg W; iAMB - Institute of Applied Microbiology, ABBt - Aachen Biology and Biotechnology, RWTH Aachen University, Worringerweg 1, D-52074 Aachen, Germany; BioSC, c/o Forschungszentrum Jülich, D-52425 Jülich, Germany.
Büttner L; Department of Biology, Philipps-University Marburg, Karl-von-Frisch-Straße 8, D-35032 Marburg, Germany.
Sarikaya E; iAMB - Institute of Applied Microbiology, ABBt - Aachen Biology and Biotechnology, RWTH Aachen University, Worringerweg 1, D-52074 Aachen, Germany.
Hartog TD; Institut für Technische und Makromolekulare Chemie (ITMC), RWTH Aachen University, Worringerweg 2, D-52074 Aachen, Germany.
Klankermayer J; Institut für Technische und Makromolekulare Chemie (ITMC), RWTH Aachen University, Worringerweg 2, D-52074 Aachen, Germany.
Leitner W; Institut für Technische und Makromolekulare Chemie (ITMC), RWTH Aachen University, Worringerweg 2, D-52074 Aachen, Germany.
Bölker M; Department of Biology, Philipps-University Marburg, Karl-von-Frisch-Straße 8, D-35032 Marburg, Germany; LOEWE Center for Synthetic Microbiology (SYNMIKRO), D-35032 Marburg, Germany.
Blank LM; iAMB - Institute of Applied Microbiology, ABBt - Aachen Biology and Biotechnology, RWTH Aachen University, Worringerweg 1, D-52074 Aachen, Germany. Electronic address: lars.blank@rwth-aachen.de.
Wierckx N; iAMB - Institute of Applied Microbiology, ABBt - Aachen Biology and Biotechnology, RWTH Aachen University, Worringerweg 1, D-52074 Aachen, Germany.

Metab Eng ; 38: 427-435, 2016 11.

Article em En | MEDLINE | ID: mdl-27750034

Assuntos

4-Butirolactona/análogos & derivados; Vias Biossintéticas/genética; Família 3 do Citocromo P450/genética; Melhoramento Genético/métodos; Engenharia Metabólica/métodos; Succinatos/metabolismo; Ustilago/fisiologia; 4-Butirolactona/metabolismo; Regulação Fúngica da Expressão Gênica/genética; Redes e Vias Metabólicas/genética; Succinatos/isolamento & purificação; Regulação para Cima/genética; Ustilago/classificação

Palavras-chave

2-hydroxyparaconate; Aspergillus terreus; Itaconate; Metabolic engineering; P450 monooxygenase; Secondary metabolites; Ustilago maydis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Succinatos / Ustilago / 4-Butirolactona / Melhoramento Genético / Vias Biossintéticas / Engenharia Metabólica / Família 3 do Citocromo P450 Idioma: En Revista: Metab Eng Ano de publicação: 2016 Tipo de documento: Article

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