The Impact of Age on the Female Reproductive System.
Toxicol Pathol
; 45(1): 206-215, 2017 01.
Article
em En
| MEDLINE
| ID: mdl-27753638
ABSTRACT
Evaluation of the female reproductive system in a general toxicity setting can be challenging for the toxicologic pathologist due to the cyclic nature of the estrous and menstrual cycles, timing of puberty and reproductive senescence, and species differences. Age in particular can have a significant impact on the histologic appearance of the female reproductive system and create challenges when trying to distinguish test article-related findings from normal developmental or senescent changes. This review describes the key physiologic and histologic features of immaturity, the transition through puberty, sexual maturity, and reproductive senescence in the female reproductive system, with an emphasis on practical applications for the toxicologic pathologist, and includes recommendations for distinguishing and documenting these developmental periods. Rats and cynomolgus monkeys are used as examples throughout with correlations to clinically observed end points to better aid the toxicologic pathologist in understanding how age may impact study interpretation.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ovário
/
Maturidade Sexual
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Útero
/
Vagina
/
Envelhecimento
Tipo de estudo:
Guideline
Limite:
Animals
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Female
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Humans
Idioma:
En
Revista:
Toxicol Pathol
Ano de publicação:
2017
Tipo de documento:
Article