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Corneal confocal microscopy alterations in Sjögren's syndrome dry eye.
Lanza, Michele; Iaccarino, Stefania; Varricchi, Gilda; D'Errico, Tito; Gironi Carnevale, Ugo Antonello; Bifani, Mario.
Afiliação
  • Lanza M; Multidisciplinary Department of Medical, Surgical and Dental Sciences, Second University of Napoli, Napoli, Italy.
  • Iaccarino S; University Study Center "Grandi Apparecchiature" Second University of Napoli, Napoli, Italy.
  • Varricchi G; Department of Translational Medical Sciences, Division of Clinic Immunology and Allergy, University of Naples Federico II University, Napoli, Italy.
  • D'Errico T; Rheumatology Unit, "Santa Maria del Popolo degli Incurabili" Hospital, Napoli, Italy.
  • Gironi Carnevale UA; Multidisciplinary Department of Medical, Surgical and Dental Sciences, Second University of Napoli, Napoli, Italy.
  • Bifani M; Multidisciplinary Department of Medical, Surgical and Dental Sciences, Second University of Napoli, Napoli, Italy.
Acta Ophthalmol ; 95(5): e366-e372, 2017 Aug.
Article em En | MEDLINE | ID: mdl-27775242
PURPOSE: To evaluate light backscattering (LB) in corneal layers in patients with primary Sjögren's syndrome dry eye (SSDE) utilizing in vivo corneal confocal microscopy (IVCM) and to determine the eventual association with the lacrimal functional test values. METHODS: A complete ophthalmic evaluation, Schirmer test with and without stimulation, break-up time (BUT) and IVCM were performed on 55 patients affected by SSDE and in an age- and sex-matched cohort of healthy participants (HP). Light backscattering, measures as light reflectivity unit (LRU), detected by IVCM at Bowman's membrane (BM) at 50 µm, at 100 µm and at 200 µm deeper than BM was compared in the two groups. The correlations between LB values and lacrimal function results were evaluated. RESULTS: In patients affected by SSDE, LB was significantly higher (p < 0.001) in each corneal layer examined (+14 ± 6.33 LRU at BM), compared with HP. A good reverse correlation between the light reflectivity measures at BM with Schirmer test with (r = -0.91) and without (r = -0.90) stimulation and BUT (r = -0.88) was found. Correlations were lower in the deeper corneal layers. CONCLUSION: Even if our results should be confirmed in further studies with a larger population, these findings show that IVCM is a device able to detect alterations in corneal layers in SSDE patients related to the lacrimal function. Light backscattering (LB) could be very useful for clinical diagnosis and management of SSDE.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndromes do Olho Seco / Síndrome de Sjogren / Microscopia Confocal / Córnea Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Acta Ophthalmol Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndromes do Olho Seco / Síndrome de Sjogren / Microscopia Confocal / Córnea Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Acta Ophthalmol Ano de publicação: 2017 Tipo de documento: Article