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Cytotoxic lanostanes from fruits of Garcinia wallichii Choisy (Guttiferae).
Hongthong, Sakchai; Meesin, Jatuporn; Pailee, Phanruethai; Soorukram, Darunee; Kongsaeree, Palangpon; Prabpai, Samran; Piyachaturawat, Pawinee; Jariyawat, Surawat; Suksen, Kanoknetr; Jaipetch, Thaworn; Nuntasaen, Narong; Reutrakul, Vichai; Kuhakarn, Chutima.
Afiliação
  • Hongthong S; Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand.
  • Meesin J; Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand.
  • Pailee P; Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand.
  • Soorukram D; Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand.
  • Kongsaeree P; Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand.
  • Prabpai S; Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand.
  • Piyachaturawat P; Department of Physiology, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand.
  • Jariyawat S; Department of Physiology, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand.
  • Suksen K; Department of Physiology, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand.
  • Jaipetch T; Mahidol University, Kanchanaburi Campus, Saiyok, Kanchanaburi 71150, Thailand.
  • Nuntasaen N; The Forest Herbarium National Park, Wildlife and Plant Conservation Department, Ministry of Natural Resources and Environment, Bangkok, Thailand.
  • Reutrakul V; Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand.
  • Kuhakarn C; Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand. Electronic address: chutima.kon@mahidol.ac.th.
Bioorg Med Chem Lett ; 26(23): 5773-5779, 2016 12 01.
Article em En | MEDLINE | ID: mdl-27793565
Five new lanostanes, wallichinanes A-E (1-5) together with a known lanostane derivative 6 were isolated from the cytotoxic hexanes extract of fruits of Garcinia wallichii Choisy (Guttiferae). The structures of the isolated compounds were established by analysis of spectroscopic data, X-ray diffraction technique as well as comparison with the literature data. The cytotoxicity of all isolated compounds against a panel of cultured cancer cell lines was evaluated. Compound 4 exhibited good cytotoxicity with ED50 values ranging from 3.91 to 7.63µM.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Garcinia / Lanosterol / Antineoplásicos Fitogênicos Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Garcinia / Lanosterol / Antineoplásicos Fitogênicos Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Ano de publicação: 2016 Tipo de documento: Article