Historical perspectives and future directions of gene-modified T-cell therapy.
Rinsho Ketsueki
; 57(10): 2241-2249, 2016.
Article
em Ja
| MEDLINE
| ID: mdl-27795536
ABSTRACT
Adoptive immunotherapy using genetically modified T-cells is an emerging and promising treatment modality for various malignant diseases. The technology involves engineering of T-cells armed with well-characterized receptors such as T-cell receptors or chimeric antigen receptors. The latter is comprised of antibody/ligand and intracellular signaling domains. These molecules can be further modified to enhance their affinity, specificity, and several other functions. The success of adoptive immunotherapy is rooted in the application of extensive insights derived from allogeneic hematopoietic stem cell transplantations (HSCT). Herein, the historical perspectives of gene-modified T-cell therapy are discussed by comparison with the evolution of allogeneic HSCT. Furthermore, the prospects for the development and improvement of these powerful therapeutic methods are also highlighted.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de Antígenos de Linfócitos T
/
Linfócitos T
/
Terapia Genética
/
Leucemia
/
Terapia Baseada em Transplante de Células e Tecidos
Limite:
Animals
/
Humans
Idioma:
Ja
Revista:
Rinsho Ketsueki
Ano de publicação:
2016
Tipo de documento:
Article