Pattern recognition receptor immunomodulation of innate immunity as a strategy to limit the impact of influenza virus.
J Leukoc Biol
; 101(4): 851-861, 2017 04.
Article
em En
| MEDLINE
| ID: mdl-27810944
ABSTRACT
Influenza remains a major global health issue and the effectiveness of current vaccines and antiviral drugs is limited by the continual evolution of influenza viruses. Therefore, identifying novel prophylactic or therapeutic treatments that induce appropriate innate immune responses to protect against influenza infection would represent an important advance in efforts to limit the impact of influenza. Cellular pattern recognition receptors (PRRs) recognize conserved structures expressed by pathogens to trigger intracellular signaling cascades, promoting expression of proinflammatory molecules and innate immunity. Therefore, a number of approaches have been developed to target specific PRRs in an effort to stimulate innate immunity and reduce disease in a variety of settings, including during influenza infections. Herein, we discuss progress in immunomodulation strategies designed to target cell-associated PRRs of the innate immune system, thereby, modifying innate responses to IAV infection and/or augmenting immune responses to influenza vaccines.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Orthomyxoviridae
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Receptores de Reconhecimento de Padrão
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Imunomodulação
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Imunidade Inata
Limite:
Animals
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Humans
Idioma:
En
Revista:
J Leukoc Biol
Ano de publicação:
2017
Tipo de documento:
Article