Synergistic antitumor activity of the combination of salubrinal and rapamycin against human cholangiocarcinoma cells.

Zhao, Xiaofang; Zhang, Chunyan; Zhou, Hong; Xiao, Bin; Cheng, Ying; Wang, Jinju; Yao, Fuli; Duan, Chunyan; Chen, Run; Liu, Youping; Feng, Chunhong; Li, Hong; Li, Jing; Dai, Rongyang

Zhao, Xiaofang; Zhang, Chunyan; Zhou, Hong; Xiao, Bin; Cheng, Ying; Wang, Jinju; Yao, Fuli; Duan, Chunyan; Chen, Run; Liu, Youping; Feng, Chunhong; Li, Hong; Li, Jing; Dai, Rongyang.

Afiliação

Zhao X; Department of Biochemistry and Molecular Biology, Southwest Medical University, Luzhou, Sichuan, China.
Zhang C; Department of Biochemistry and Molecular Biology, Southwest Medical University, Luzhou, Sichuan, China.
Zhou H; Department of Biochemistry and Molecular Biology, Southwest Medical University, Luzhou, Sichuan, China.
Xiao B; Department of Biochemistry and Molecular Biology, Southwest Medical University, Luzhou, Sichuan, China.
Cheng Y; Department of Biochemistry and Molecular Biology, Southwest Medical University, Luzhou, Sichuan, China.
Wang J; Department of Hepatobiliary Surgery of the Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Yao F; Department of Biochemistry and Molecular Biology, Southwest Medical University, Luzhou, Sichuan, China.
Duan C; Department of Biochemistry and Molecular Biology, Southwest Medical University, Luzhou, Sichuan, China.
Chen R; Department of Public Health, Southwest Medical University, Luzhou, Sichuan, China.
Liu Y; Department of Hepatobiliary Surgery of the Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Feng C; Department of Hepatobiliary Surgery of the Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Li H; Department of Biochemistry and Molecular Biology, Southwest Medical University, Luzhou, Sichuan, China.
Li J; Department of Hepatobiliary Surgery of the Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Dai R; Department of Biochemistry and Molecular Biology, Southwest Medical University, Luzhou, Sichuan, China.

Oncotarget ; 7(51): 85492-85501, 2016 Dec 20.

Article em En | MEDLINE | ID: mdl-27863431

Assuntos

Protocolos de Quimioterapia Combinada Antineoplásica/farmacologia; Neoplasias dos Ductos Biliares/tratamento farmacológico; Colangiocarcinoma/tratamento farmacológico; Cinamatos/farmacologia; Sirolimo/farmacologia; Tioureia/análogos & derivados; Animais; Neoplasias dos Ductos Biliares/metabolismo; Neoplasias dos Ductos Biliares/patologia; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Colangiocarcinoma/metabolismo; Colangiocarcinoma/patologia; Sinergismo Farmacológico; Fator de Iniciação 2 em Eucariotos/antagonistas & inibidores; Fator de Iniciação 2 em Eucariotos/metabolismo; Humanos; Masculino; Camundongos Nus; Fosforilação; Proteínas Proto-Oncogênicas c-akt/antagonistas & inibidores; Proteínas Proto-Oncogênicas c-akt/metabolismo; Transdução de Sinais/efeitos dos fármacos; Serina-Treonina Quinases TOR/antagonistas & inibidores; Serina-Treonina Quinases TOR/metabolismo; Tioureia/farmacologia; Fatores de Tempo; Carga Tumoral/efeitos dos fármacos; Ensaios Antitumorais Modelo de Xenoenxerto; Proteína bcl-X/metabolismo

Palavras-chave

Akt; Bcl-xL; cholangiocarcinoma; rapamycin; salubrinal

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tioureia / Neoplasias dos Ductos Biliares / Protocolos de Quimioterapia Combinada Antineoplásica / Cinamatos / Colangiocarcinoma / Sirolimo Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Oncotarget Ano de publicação: 2016 Tipo de documento: Article

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