Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy.

Baird, Angela C; Mallon, Dominic; Radford-Smith, Graham; Boyer, Julien; Piche, Thierry; Prescott, Susan L; Lawrance, Ian C; Tulic, Meri K

Baird, Angela C; Mallon, Dominic; Radford-Smith, Graham; Boyer, Julien; Piche, Thierry; Prescott, Susan L; Lawrance, Ian C; Tulic, Meri K.

Afiliação

Baird AC; Angela C Baird, Ian C Lawrance, Faculty of Medicine and Dentistry, School of Medicine and Pharmacology, University of Western Australia, Perth, WA 6009, Australia.
Mallon D; Angela C Baird, Ian C Lawrance, Faculty of Medicine and Dentistry, School of Medicine and Pharmacology, University of Western Australia, Perth, WA 6009, Australia.
Radford-Smith G; Angela C Baird, Ian C Lawrance, Faculty of Medicine and Dentistry, School of Medicine and Pharmacology, University of Western Australia, Perth, WA 6009, Australia.
Boyer J; Angela C Baird, Ian C Lawrance, Faculty of Medicine and Dentistry, School of Medicine and Pharmacology, University of Western Australia, Perth, WA 6009, Australia.
Piche T; Angela C Baird, Ian C Lawrance, Faculty of Medicine and Dentistry, School of Medicine and Pharmacology, University of Western Australia, Perth, WA 6009, Australia.
Prescott SL; Angela C Baird, Ian C Lawrance, Faculty of Medicine and Dentistry, School of Medicine and Pharmacology, University of Western Australia, Perth, WA 6009, Australia.
Lawrance IC; Angela C Baird, Ian C Lawrance, Faculty of Medicine and Dentistry, School of Medicine and Pharmacology, University of Western Australia, Perth, WA 6009, Australia.
Tulic MK; Angela C Baird, Ian C Lawrance, Faculty of Medicine and Dentistry, School of Medicine and Pharmacology, University of Western Australia, Perth, WA 6009, Australia.

World J Gastroenterol ; 22(41): 9104-9116, 2016 Nov 07.

Article em En | MEDLINE | ID: mdl-27895398

Assuntos

Anti-Inflamatórios/uso terapêutico; Produtos Biológicos/uso terapêutico; Colite Ulcerativa/tratamento farmacológico; Fármacos Gastrointestinais/uso terapêutico; Imunidade Inata/efeitos dos fármacos; Fator de Necrose Tumoral alfa/antagonistas & inibidores; Adolescente; Adulto; Células Cultivadas; Criança; Colite Ulcerativa/sangue; Colite Ulcerativa/diagnóstico; Colite Ulcerativa/imunologia; Células Dendríticas/efeitos dos fármacos; Células Dendríticas/imunologia; Células Dendríticas/metabolismo; Feminino; Humanos; Quinases Associadas a Receptores de Interleucina-1/imunologia; Quinases Associadas a Receptores de Interleucina-1/metabolismo; Leucócitos Mononucleares/efeitos dos fármacos; Leucócitos Mononucleares/imunologia; Leucócitos Mononucleares/metabolismo; Masculino; Pessoa de Meia-Idade; Estudos Prospectivos; Estudos Retrospectivos; Transdução de Sinais/efeitos dos fármacos; Linfócitos T Reguladores/efeitos dos fármacos; Linfócitos T Reguladores/imunologia; Linfócitos T Reguladores/metabolismo; Receptores Toll-Like/imunologia; Receptores Toll-Like/metabolismo; Falha de Tratamento; Fator de Necrose Tumoral alfa/sangue; Fator de Necrose Tumoral alfa/imunologia; Adulto Jovem

Palavras-chave

Anti-tumor necrosis factor therapy; IRAK4; Inflammatory bowel disease; Innate immunity; Toll-like receptor; Ulcerative colitis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Produtos Biológicos / Fármacos Gastrointestinais / Colite Ulcerativa / Fator de Necrose Tumoral alfa / Imunidade Inata / Anti-Inflamatórios Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Idioma: En Revista: World J Gastroenterol Ano de publicação: 2016 Tipo de documento: Article

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