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Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor.
Gustafsson, Robert; Jemth, Ann-Sofie; Gustafsson, Nina M S; Färnegårdh, Katarina; Loseva, Olga; Wiita, Elisée; Bonagas, Nadilly; Dahllund, Leif; Llona-Minguez, Sabin; Häggblad, Maria; Henriksson, Martin; Andersson, Yasmin; Homan, Evert; Helleday, Thomas; Stenmark, Pål.
Afiliação
  • Gustafsson R; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
  • Jemth AS; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
  • Gustafsson NM; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
  • Färnegårdh K; Drug Discovery and Development Platform, Science for Life Laboratory, Department of Organic Chemistry, Stockholm University, Solna, Sweden.
  • Loseva O; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
  • Wiita E; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
  • Bonagas N; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
  • Dahllund L; Drug Discovery and Development Platform, Science for Life Laboratory, School of Biotechnology, Royal Institute of Technology, Solna, Sweden.
  • Llona-Minguez S; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
  • Häggblad M; Biochemical and Cellular Screening, Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
  • Henriksson M; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
  • Andersson Y; Drug Discovery and Development Platform, Science for Life Laboratory, School of Biotechnology, Royal Institute of Technology, Solna, Sweden.
  • Homan E; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
  • Helleday T; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. stenmark@dbb.su.se thomas.helleday@scilifelab.se.
  • Stenmark P; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden. stenmark@dbb.su.se thomas.helleday@scilifelab.se.
Cancer Res ; 77(4): 937-948, 2017 02 15.
Article em En | MEDLINE | ID: mdl-27899380
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Meteniltetra-Hidrofolato Cicloidrolase / Inibidores Enzimáticos / Metilenotetra-Hidrofolato Desidrogenase (NADP) / Mitocôndrias Limite: Humans Idioma: En Revista: Cancer Res Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Meteniltetra-Hidrofolato Cicloidrolase / Inibidores Enzimáticos / Metilenotetra-Hidrofolato Desidrogenase (NADP) / Mitocôndrias Limite: Humans Idioma: En Revista: Cancer Res Ano de publicação: 2017 Tipo de documento: Article