Metastatic spinal cord compression from basal cell carcinoma of the skin treated with surgical decompression and vismodegib: case report and review of Hedgehog signalling pathway inhibition in advanced basal cell carcinoma.
Clin Exp Dermatol
; 42(1): 80-83, 2017 Jan.
Article
em En
| MEDLINE
| ID: mdl-27905158
We report a case of a 66-year-old man with locally advanced and metastatic basal cell carcinoma (BCC) causing spinal cord compression, which was treated with spinal surgery and subsequent vismodegib. The patient presented with a large fungating chest wall lesion and a metastasis in T8 that was causing cord compression. He had neurosurgical decompression of the T8 lesion and fixation of the spine. Punch biopsy from the fungating chest wall lesion showed a BCC with some malignant squamous differentiation (basosquamous). Histopathological examination of the metastatic lesion in T8 at the time of surgical decompression identified features identical to the punch biopsy. The patient was referred to the oncology clinic for adjuvant treatment. In light of his metastatic disease and the large area over his chest wall that could not fully be covered by radiotherapy, he was treated with the novel oral Hedgehog signalling pathway (HHSP) inhibitor vismodegib, which led to marked improvement.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piridinas
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Neoplasias Cutâneas
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Compressão da Medula Espinal
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Neoplasias da Medula Espinal
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Carcinoma Basocelular
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Descompressão Cirúrgica
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Proteínas Hedgehog
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Anilidas
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Aged
/
Animals
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Humans
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Male
Idioma:
En
Revista:
Clin Exp Dermatol
Ano de publicação:
2017
Tipo de documento:
Article