Successful group psychotherapy of depression in adolescents alters fronto-limbic resting-state connectivity.
J Affect Disord
; 209: 135-139, 2017 Feb.
Article
em En
| MEDLINE
| ID: mdl-27912160
ABSTRACT
BACKGROUND:
Current resting state imaging findings support suggestions that the neural signature of depression and therefore also its therapy should be conceptualized as a network disorder rather than a dysfunction of specific brain regions. In this study, we compared neural connectivity of adolescent patients with depression (PAT) and matched healthy controls (HC) and analysed pre-to-post changes of seed-based network connectivities in PAT after participation in a cognitive behavioral group psychotherapy (CBT).METHODS:
38 adolescents (30 female; 19 patients; 13-18 years) underwent an eyes-closed resting-state scan. PAT were scanned before (pre) and after (post) five sessions of CBT. Resting-state functional connectivity was analysed in a seed-based approach for right-sided amygdala and subgenual anterior cingulate cortex (sgACC). Symptom severity was assessed using the Beck Depression Inventory Revision (BDI-II).RESULTS:
Prior to group CBT, between groups amygdala and sgACC connectivity with regions of the default mode network was stronger in the patients group relative to controls. Within the PAT group, a similar pattern significantly decreased after successful CBT. Conversely, seed-based connectivity with affective regions and regions processing cognition and salient stimuli was stronger in HC relative to PAT before CBT. Within the PAT group, a similar pattern changed with CBT. Changes in connectivity correlated with the significant pre-to-post symptom improvement, and pre-treatment amygdala connectivity predicted treatment response in depressed adolescents.LIMITATIONS:
Sample size and missing long-term follow-up limit the interpretability.CONCLUSIONS:
Successful group psychotherapy of depression in adolescents involved connectivity changes in resting state networks to that of healthy controls.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Psicoterapia de Grupo
/
Descanso
/
Terapia Cognitivo-Comportamental
/
Transtorno Depressivo
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
/
Female
/
Humans
Idioma:
En
Revista:
J Affect Disord
Ano de publicação:
2017
Tipo de documento:
Article