Functionalized gold nanoparticles manifested as potent carriers for nucleolar targeting.
Nanotechnology
; 28(2): 025103, 2017 Jan 13.
Article
em En
| MEDLINE
| ID: mdl-27924783
ABSTRACT
It is generally known that gold nanoparticles are localised in the cytoplasm and, if synthesised in small sizes or functionalized with specific proteins, they enter the cell nucleus. However, there is no report emphasising the importance of surface functionalization in their accumulation in the nucleolus. Here, for the first time in the literature, it is proposed that functionalization of gold nanoparticles with a thin layer of polyethyleneimine (PEI) spearheads them to the nucleolus of hard-to-transfect post-mitotic dorsal root ganglion neurones in a size-independent manner. As a potential for theranostic applications, it was found that functionalization with a thin layer of PEI affected the emission signal intensity of gold nanoparticles so that the cellular biodistribution of nanoparticles was visualised clearly under both confocal and two-photon microscopes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Núcleo Celular
/
Sistemas de Liberação de Medicamentos
/
Nanopartículas Metálicas
/
Gânglios Espinais
/
Ouro
/
Neurônios
Limite:
Animals
Idioma:
En
Revista:
Nanotechnology
Ano de publicação:
2017
Tipo de documento:
Article