High-throughput compound evaluation on 3D networks of neurons and glia in a microfluidic platform.
Sci Rep
; 6: 38856, 2016 12 09.
Article
em En
| MEDLINE
| ID: mdl-27934939
ABSTRACT
With great advances in the field of in vitro brain modelling, the challenge is now to implement these technologies for development and evaluation of new drug candidates. Here we demonstrate a method for culturing three-dimensional networks of spontaneously active neurons and supporting glial cells in a microfluidic platform. The high-throughput nature of the platform in combination with its compatibility with all standard laboratory equipment allows for parallel evaluation of compound effects.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Organoides
/
Neuroglia
/
Técnicas de Cultura de Células
/
Ensaios de Triagem em Larga Escala
/
Dispositivos Lab-On-A-Chip
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Células-Tronco Neurais
/
Neurônios
Limite:
Humans
Idioma:
En
Revista:
Sci Rep
Ano de publicação:
2016
Tipo de documento:
Article