Synthesis and in-vitro anti-leishmanial activity of (4-arylpiperazin-1-yl)(1-(thiophen-2-yl)-9H-pyrido[3,4-b]indol-3-yl)methanone derivatives.

Ashok, Penta; Chander, Subhash; Chow, Larry M C; Wong, Iris L K; Singh, Rajnish Prakash; Jha, Prabhat Nath; Sankaranarayanan, Murugesan

Ashok, Penta; Chander, Subhash; Chow, Larry M C; Wong, Iris L K; Singh, Rajnish Prakash; Jha, Prabhat Nath; Sankaranarayanan, Murugesan.

Afiliação

Ashok P; Medicinal Chemistry Research Laboratory, Department of Pharmacy, Birla Institute of Technology & Science, Pilani 333031, India. Electronic address: penta.ashok@gmail.com.
Chander S; Medicinal Chemistry Research Laboratory, Department of Pharmacy, Birla Institute of Technology & Science, Pilani 333031, India.
Chow LM; Department of Applied Biology and Chemical Technology and State Key Laboratory of Chirosciences, The Hong Kong Polytechnic University, Hong Kong. Electronic address: larry.chow@polyu.edu.hk.
Wong IL; Department of Applied Biology and Chemical Technology and State Key Laboratory of Chirosciences, The Hong Kong Polytechnic University, Hong Kong.
Singh RP; Department of Biological Sciences, Birla Institute of Technology & Science, Pilani 333031, Rajasthan, India.
Jha PN; Department of Biological Sciences, Birla Institute of Technology & Science, Pilani 333031, Rajasthan, India.
Sankaranarayanan M; Medicinal Chemistry Research Laboratory, Department of Pharmacy, Birla Institute of Technology & Science, Pilani 333031, India. Electronic address: murugesan@pilani.bits-pilani.ac.in.

Bioorg Chem ; 70: 100-106, 2017 02.

Article em En | MEDLINE | ID: mdl-27939960

Assuntos

Antiprotozoários/química; Antiprotozoários/farmacologia; Indóis/química; Indóis/farmacologia; Leishmania/efeitos dos fármacos; Tiofenos/química; Tiofenos/farmacologia; Animais; Células Cultivadas; Humanos; Leishmania donovani/efeitos dos fármacos; Leishmaniose/tratamento farmacológico; Leishmaniose/parasitologia; Macrófagos/parasitologia; Camundongos

Palavras-chave

Amastigote; Leishmaniasis; Promastigote; ß-carboline

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 / 3_ND Base de dados: MEDLINE Assunto principal: Tiofenos / Indóis / Leishmania / Antiprotozoários Limite: Animals / Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2017 Tipo de documento: Article

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