Respective role of the dorsal hippocampus and the entorhinal cortex during the recombination of previously learned olfactory-tactile associations in the rat.
Learn Mem
; 24(1): 24-34, 2017 01.
Article
em En
| MEDLINE
| ID: mdl-27980073
ABSTRACT
The hippocampal formation has been extensively described as a key component for object recognition in conjunction with place and context. The present study aimed at describing neural mechanisms in the hippocampal formation that support olfactory-tactile (OT) object discrimination in a task where space and context were not taken into account. The task consisted in discriminating one baited cup among three, each of them presenting overlapping olfactory or tactile elements. The experiment tested the involvement of the entorhinal cortex (EC) and the dorsal hippocampus (DH) in the acquisition of this cross-modal task, either with new items or with familiar but recombined items. The main results showed that DH inactivation or cholinergic muscarinic blockade in the DH selectively and drastically disrupted performance in the recombination task. EC inactivation impaired OT acquisition of any OT combinations while cholinergic blockade only delayed it. Control experiments showed that neither DH nor EC inactivation impaired unimodal olfactory or tactile tasks. As a whole, these data suggest that DH-EC interactions are of importance for flexibility of cross-modal representations with overlapping elements.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aprendizagem por Associação
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Olfato
/
Tato
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Córtex Entorrinal
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Aprendizagem por Discriminação
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Hipocampo
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Vias Neurais
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Learn Mem
Ano de publicação:
2017
Tipo de documento:
Article