Solving Immunology?
Trends Immunol
; 38(2): 116-127, 2017 02.
Article
em En
| MEDLINE
| ID: mdl-27986392
ABSTRACT
Emergent responses of the immune system result from the integration of molecular and cellular networks over time and across multiple organs. High-content and high-throughput analysis technologies, concomitantly with data-driven and mechanistic modeling, hold promise for the systematic interrogation of these complex pathways. However, connecting genetic variation and molecular mechanisms to individual phenotypes and health outcomes has proven elusive. Gaps remain in data, and disagreements persist about the value of mechanistic modeling for immunology. Here, we present the perspectives that emerged from the National Institute of Allergy and Infectious Disease (NIAID) workshop 'Complex Systems Science, Modeling and Immunity' and subsequent discussions regarding the potential synergy of high-throughput data acquisition, data-driven modeling, and mechanistic modeling to define new mechanisms of immunological disease and to accelerate the translation of these insights into therapies.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
Base de dados:
MEDLINE
Assunto principal:
Sistemas de Gerenciamento de Base de Dados
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Modelos Imunológicos
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Biologia de Sistemas
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Sistema Imunitário
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Imunidade
Limite:
Animals
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Humans
Idioma:
En
Revista:
Trends Immunol
Ano de publicação:
2017
Tipo de documento:
Article