Methanolic bark extract of Acacia catechu ameliorates benzo(a)pyrene induced lung toxicity by abrogation of oxidative stress, inflammation, and apoptosis in mice.

Shahid, Ayaz; Ali, Rashid; Ali, Nemat; Kazim Hasan, Syed; Barnwal, Preeti; Mohammad Afzal, Shekh; Vafa, Abul; Sultana, Sarwat

Shahid, Ayaz; Ali, Rashid; Ali, Nemat; Kazim Hasan, Syed; Barnwal, Preeti; Mohammad Afzal, Shekh; Vafa, Abul; Sultana, Sarwat.

Afiliação

Shahid A; Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi, 110062, India.
Ali R; Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi, 110062, India.
Ali N; Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi, 110062, India.
Kazim Hasan S; Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi, 110062, India.
Barnwal P; Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi, 110062, India.
Mohammad Afzal S; Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi, 110062, India.
Vafa A; Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi, 110062, India.
Sultana S; Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi, 110062, India.

Environ Toxicol ; 32(5): 1566-1577, 2017 May.

Article em En | MEDLINE | ID: mdl-28032951

Assuntos

Acacia/química; Apoptose/efeitos dos fármacos; Benzo(a)pireno/toxicidade; Pulmão/efeitos dos fármacos; Estresse Oxidativo/efeitos dos fármacos; Extratos Vegetais/farmacologia; Pneumonia/prevenção & controle; Animais; Antioxidantes/metabolismo; Carcinógenos/toxicidade; Caspase 3/metabolismo; Citoproteção/efeitos dos fármacos; Glutationa/metabolismo; Pulmão/fisiologia; Masculino; Metanol/química; Camundongos; NF-kappa B/metabolismo; Casca de Planta/química; Extratos Vegetais/química; Pneumonia/induzido quimicamente; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

antioxidants; apoptosis; bcl-2; histopathology; lung toxicity

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 4_TD / 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Pneumonia / Benzo(a)pireno / Extratos Vegetais / Apoptose / Estresse Oxidativo / Acacia / Pulmão Limite: Animals Idioma: En Revista: Environ Toxicol Ano de publicação: 2017 Tipo de documento: Article

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