Phytochemical Investigations of Three Rhodocodon (Hyacinthaceae Sensu APG II) Species.
J Nat Prod
; 80(1): 30-37, 2017 01 27.
Article
em En
| MEDLINE
| ID: mdl-28051316
ABSTRACT
The genus Rhodocodon (Hyacinthaceae sensu APG II) is endemic to Madagascar, and its phytochemistry has not been described previously. The phytochemistry of three species in this genus has been investigated, and eight compounds, including three bufadienolides (compounds 1, 4, and 5), a norlignan (2), and four homoisoflavonoids (compounds 3 and 6-8), have been isolated and identified. Compounds 1-3 and 6-8 have not been described previously. The COX-2 inhibitory activity of compound 6 and compound 7 acetate (compound 7A) was investigated on isolated colorectal cancer cells. Compounds 6 and 7A inhibited COX-2 by 10% and 8%, respectively, at a concentration of 12.5 µM compared to 12% for 1 mM aspirin (the positive control).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bufanolídeos
/
Extratos Vegetais
/
Lignanas
/
Liliaceae
/
Inibidores de Ciclo-Oxigenase 2
/
Asparagaceae
/
Isoflavonas
/
Lactonas
Limite:
Humans
País/Região como assunto:
Africa
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2017
Tipo de documento:
Article