Intraplantar injection of sialidase reduces mechanical allodynia during inflammatory pain.
J Pharmacol Sci
; 133(1): 49-52, 2017 Jan.
Article
em En
| MEDLINE
| ID: mdl-28089228
ABSTRACT
Sialic acids are highly charged glycoresidues that are attached to glycoproteins or glycosphingolipids, and they are associated with various biological functions. Gangliosides, sialic acid-containing glycosphingolipids, are abundant in neural tissues and play important roles in the nervous system. Previous studies revealed that peripheral gangliosides are involved in nociceptive behavior and hyperalgesia. These observations prompted us to determine whether the sialic acid-cleaving enzyme sialidase affects pain signaling. Intraplantar injection of sialidase reduced mechanical allodynia during complete Freund's adjuvant-induced inflammation. We also found that ganglioside induces mechanical allodynia in naïve mice. These results suggest that sialyl conjugates in subcutaneous tissues modify allodynia.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
Base de dados:
MEDLINE
Assunto principal:
Hiperalgesia
/
Inflamação
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Neuraminidase
Limite:
Animals
Idioma:
En
Revista:
J Pharmacol Sci
Ano de publicação:
2017
Tipo de documento:
Article