Intracerebroventricular Delivery as a Safe, Long-Term Route of Drug Administration.
Pediatr Neurol
; 67: 23-35, 2017 02.
Article
em En
| MEDLINE
| ID: mdl-28089765
ABSTRACT
Intrathecal delivery methods have been used for many decades to treat a broad range of central nervous system disorders. A literature review demonstrated that intracerebroventricular route is an established and well-tolerated method for prolonged central nervous system drug delivery in pediatric and adult populations. Intracerebroventricular devices were present in patients from one to 7156 days. The number of punctures per device ranged from 2 to 280. Noninfectious complication rates per patient (range, 1.0% to 33.0%) were similar to infectious complication rates (0.0% to 27.0%). Clinician experience and training and the use of strict aseptic techniques have been shown to reduce the frequency of complications.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Injeções Espinhais
/
Fármacos do Sistema Nervoso Central
Limite:
Humans
Idioma:
En
Revista:
Pediatr Neurol
Ano de publicação:
2017
Tipo de documento:
Article