Metformin vs myoinositol: which is better in obese polycystic ovary syndrome patients? A randomized controlled crossover study.
Clin Endocrinol (Oxf)
; 86(5): 725-730, 2017 May.
Article
em En
| MEDLINE
| ID: mdl-28092404
ABSTRACT
CONTEXT Due to the central role of metabolic abnormalities in the pathophysiology of polycystic ovary syndrome (PCOS), insulin sensitizing agents have been proposed as a feasible treatment option. OBJECTIVE:
To investigate which is the more effective between metformin and myoinositol (MYO) on hormonal, clinical and metabolic parameters in obese patients with PCOS. STUDYDESIGN:
Crossover randomized controlled study. PATIENTS Thirty-four PCOS obese women (age 25·62 ± 4·7 years; BMI 32·55 ± 5·67 kg/m2 ) were randomized to receive metformin (850 mg twice a day) or MYO (1000 mg twice a day) for 6 months. After a 3 month washout, the same subjects received the other compound for the following 6 months. MEASUREMENTS Ultrasonographic pelvic examinations, hirsutism score, anthropometric and menstrual pattern evaluation, hormonal profile assays, oral glucose tolerance test (OGTT) and lipid profile at baseline and after 6 months of treatment were performed.RESULTS:
Both metformin and MYO significantly reduced the insulin response to OGTT and improved insulin sensitivity. Metformin significantly decreased body weight and improved menstrual pattern and Ferriman-Gallwey score. Metformin treatment was also associated with a significant decrease in LH and oestradiol levels, androgens and anti-müllerian hormone levels. None of these clinical and hormonal changes were observed during MYO administration.CONCLUSIONS:
Both treatments improved the glyco-insulinaemic features of obese PCOS patients, but only metformin seems to exert a beneficial effect on the endocrine and clinical features of the syndrome.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
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2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Síndrome do Ovário Policístico
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Avaliação de Resultados em Cuidados de Saúde
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Hipoglicemiantes
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Inositol
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Metformina
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Obesidade
Tipo de estudo:
Clinical_trials
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Etiology_studies
Limite:
Adult
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Female
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Humans
Idioma:
En
Revista:
Clin Endocrinol (Oxf)
Ano de publicação:
2017
Tipo de documento:
Article