Motuporamine Derivatives as Antimicrobial Agents and Antibiotic Enhancers against Resistant Gram-Negative Bacteria.
Chembiochem
; 18(3): 276-283, 2017 02 01.
Article
em En
| MEDLINE
| ID: mdl-28098416
ABSTRACT
Dihydromotuporamineâ
C and its derivatives were evaluated for their in vitro antimicrobial activities and antibiotic enhancement properties against Gram-negative bacteria and clinical isolates. The mechanism of action of one of these derivatives, MOTU-N44, was investigated against Enterobacter aerogenes by using fluorescent dyes to evaluate outer-membrane depolarization and permeabilization. Its efficiency correlated with inhibition of dye transport, thus suggesting that these molecules inhibit drug transporters by de-energization of the efflux pump rather than by direct interaction of the molecule with the pump. This suggests that depowering the efflux pump provides another strategy to address antibiotic resistance.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Poliaminas
/
Farmacorresistência Bacteriana Múltipla
/
Alcaloides
/
Bactérias Gram-Negativas
/
Compostos Heterocíclicos com 1 Anel
/
Anti-Infecciosos
/
Antibacterianos
Idioma:
En
Revista:
Chembiochem
Ano de publicação:
2017
Tipo de documento:
Article