Therapeutic Potential of Targeting the Th17/Treg Axis in Autoimmune Disorders.
Molecules
; 22(1)2017 Jan 14.
Article
em En
| MEDLINE
| ID: mdl-28098832
A disruption of the crucial balance between regulatory T-cells (Tregs) and Th17-cells was recently implicated in various autoimmune disorders. Tregs are responsible for the maintenance of self-tolerance, thus inhibiting autoimmunity, whereas pro-inflammatory Th17-cells contribute to the induction and propagation of inflammation. Distortion of the Th17/Treg balance favoring the pro-inflammatory Th17 side is hence suspected to contribute to exacerbation of autoimmune disorders. This review aims to summarize recent data and advances in targeted therapeutic modification of the Th17/Treg-balance, as well as information on the efficacy of candidate therapeutics with respect to the treatment of autoimmune diseases.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
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Linfócitos T Reguladores
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Fatores de Transcrição Forkhead
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Membro 3 do Grupo F da Subfamília 1 de Receptores Nucleares
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Células Th17
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Fatores Imunológicos
Limite:
Animals
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Humans
Idioma:
En
Revista:
Molecules
Ano de publicação:
2017
Tipo de documento:
Article