White Ginseng Protects Mouse Hippocampal Cells Against Amyloid-Beta Oligomer Toxicity.
Phytother Res
; 31(3): 497-506, 2017 Mar.
Article
em En
| MEDLINE
| ID: mdl-28112442
Amyloid-beta oligomer (AßO) is a soluble oligomer form of the Aß peptide and the most potent amyloid-beta form that induces neuronal damage in Alzheimer's disease. We investigated the effect of dried white ginseng extract (WGE) on neuronal cell damage and memory impairment in intrahippocampal AßO (10 µM)-injected mice. Mice were treated with WGE (100 and 500 mg/kg/day, p.o.) for 12 days after surgery. WGE improved memory impairment by inhibiting hippocampal cell death caused by AßO. In addition, AßO-injected mice treated with WGE showed restoration of reduced synaptophysin and choline acetyltransferase intensity and lower levels of ionized calcium-binding adaptor molecule 1 in the hippocampus compared with those of vehicle-treated controls. These results suggest that WGE reverses memory impairment in Alzheimer's disease by attenuating neuronal damage and neuroinflammation in the AßO-injected mouse hippocampus. Copyright © 2017 John Wiley & Sons, Ltd.
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Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
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6_ODS3_enfermedades_notrasmisibles
Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
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Peptídeos beta-Amiloides
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Fármacos Neuroprotetores
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Panax
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Hipocampo
Limite:
Animals
Idioma:
En
Revista:
Phytother Res
Ano de publicação:
2017
Tipo de documento:
Article