Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNa<sub>V</sub>1.7.

Agwa, Akello J; Lawrence, Nicole; Deplazes, Evelyne; Cheneval, Olivier; Chen, Rachel M; Craik, David J; Schroeder, Christina I; Henriques, Sónia T

Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNa_V1.7.

Agwa, Akello J; Lawrence, Nicole; Deplazes, Evelyne; Cheneval, Olivier; Chen, Rachel M; Craik, David J; Schroeder, Christina I; Henriques, Sónia T.

Afiliação

Agwa AJ; Institute for Molecular Bioscience, The University of Queensland, Qld 4072, Australia.
Lawrence N; Institute for Molecular Bioscience, The University of Queensland, Qld 4072, Australia.
Deplazes E; Institute for Molecular Bioscience, The University of Queensland, Qld 4072, Australia; School of Chemistry and Molecular Biosciences, The University of Queensland, Qld 4072, Australia.
Cheneval O; Institute for Molecular Bioscience, The University of Queensland, Qld 4072, Australia.
Chen RM; Institute for Molecular Bioscience, The University of Queensland, Qld 4072, Australia.
Craik DJ; Institute for Molecular Bioscience, The University of Queensland, Qld 4072, Australia.
Schroeder CI; Institute for Molecular Bioscience, The University of Queensland, Qld 4072, Australia. Electronic address: c.schroeder@imb.uq.edu.au.
Henriques ST; Institute for Molecular Bioscience, The University of Queensland, Qld 4072, Australia. Electronic address: s.henriques@uq.edu.au.

Biochim Biophys Acta Biomembr ; 1859(5): 835-844, 2017 May.

Article em En | MEDLINE | ID: mdl-28115115

Assuntos

Bicamadas Lipídicas/metabolismo; Canal de Sódio Disparado por Voltagem NAV1.7/efeitos dos fármacos; Bloqueadores dos Canais de Sódio/farmacologia; Venenos de Aranha/farmacologia; Fenômenos Biofísicos; Humanos; Espectroscopia de Ressonância Magnética; Espectrometria de Fluorescência; Venenos de Aranha/metabolismo; Ressonância de Plasmônio de Superfície

Palavras-chave

Drug design; Gating modifier toxin; Huwentoxin; Pain therapeutic; Peptide-membrane interactions; Venom peptide

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Venenos de Aranha / Bloqueadores dos Canais de Sódio / Canal de Sódio Disparado por Voltagem NAV1.7 / Bicamadas Lipídicas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Biochim Biophys Acta Biomembr Ano de publicação: 2017 Tipo de documento: Article

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