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Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library.
Ahn, Seungkirl; Kahsai, Alem W; Pani, Biswaranjan; Wang, Qin-Ting; Zhao, Shuai; Wall, Alissa L; Strachan, Ryan T; Staus, Dean P; Wingler, Laura M; Sun, Lillian D; Sinnaeve, Justine; Choi, Minjung; Cho, Ted; Xu, Thomas T; Hansen, Gwenn M; Burnett, Michael B; Lamerdin, Jane E; Bassoni, Daniel L; Gavino, Bryant J; Husemoen, Gitte; Olsen, Eva K; Franch, Thomas; Costanzi, Stefano; Chen, Xin; Lefkowitz, Robert J.
Afiliação
  • Ahn S; Department of Medicine, Duke University Medical Center, Durham, NC 27710.
  • Kahsai AW; Department of Medicine, Duke University Medical Center, Durham, NC 27710.
  • Pani B; Department of Medicine, Duke University Medical Center, Durham, NC 27710.
  • Wang QT; Department of Medicinal Chemistry, School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou 213164, Jiangsu, China.
  • Zhao S; Department of Medicinal Chemistry, School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou 213164, Jiangsu, China.
  • Wall AL; Department of Medicine, Duke University Medical Center, Durham, NC 27710.
  • Strachan RT; Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599.
  • Staus DP; Department of Medicine, Duke University Medical Center, Durham, NC 27710.
  • Wingler LM; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710.
  • Sun LD; Department of Medicine, Duke University Medical Center, Durham, NC 27710.
  • Sinnaeve J; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710.
  • Choi M; Department of Medicine, Duke University Medical Center, Durham, NC 27710.
  • Cho T; Department of Medicine, Duke University Medical Center, Durham, NC 27710.
  • Xu TT; Department of Biochemistry, Duke University Medical Center, Durham, NC 27710.
  • Hansen GM; Department of Biology, Duke University Medical Center, Durham, NC 27710.
  • Burnett MB; Department of Medicine, Duke University Medical Center, Durham, NC 27710.
  • Lamerdin JE; Lexicon Pharmaceuticals, Inc., The Woodlands, TX 77381.
  • Bassoni DL; Lexicon Pharmaceuticals, Inc., The Woodlands, TX 77381.
  • Gavino BJ; DiscoverX Co., Fremont, CA 94538.
  • Husemoen G; DiscoverX Co., Fremont, CA 94538.
  • Olsen EK; DiscoverX Co., Fremont, CA 94538.
  • Franch T; Nuevolution A/S, 2100 Copenhagen, Denmark.
  • Costanzi S; Nuevolution A/S, 2100 Copenhagen, Denmark.
  • Chen X; Nuevolution A/S, 2100 Copenhagen, Denmark.
  • Lefkowitz RJ; Department of Chemistry, American University, Washington, DC 20016.
Proc Natl Acad Sci U S A ; 114(7): 1708-1713, 2017 02 14.
Article em En | MEDLINE | ID: mdl-28130548
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Adrenérgicos beta 2 / Antagonistas Adrenérgicos beta / Bibliotecas de Moléculas Pequenas / Ensaios de Triagem em Larga Escala Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Adrenérgicos beta 2 / Antagonistas Adrenérgicos beta / Bibliotecas de Moléculas Pequenas / Ensaios de Triagem em Larga Escala Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2017 Tipo de documento: Article