Class I-restricted T-cell responses to a polymorphic peptide in a gene therapy clinical trial for &#945;-1-antitrypsin deficiency.

Calcedo, Roberto; Somanathan, Suryanarayan; Qin, Qiuyue; Betts, Michael R; Rech, Andrew J; Vonderheide, Robert H; Mueller, Christian; Flotte, Terence R; Wilson, James M

Class I-restricted T-cell responses to a polymorphic peptide in a gene therapy clinical trial for α-1-antitrypsin deficiency.

Calcedo, Roberto; Somanathan, Suryanarayan; Qin, Qiuyue; Betts, Michael R; Rech, Andrew J; Vonderheide, Robert H; Mueller, Christian; Flotte, Terence R; Wilson, James M.

Afiliação

Calcedo R; Gene Therapy Program, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Somanathan S; Gene Therapy Program, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Qin Q; Gene Therapy Program, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Betts MR; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Rech AJ; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Vonderheide RH; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Mueller C; Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01655.
Flotte TR; Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01655.
Wilson JM; Gene Therapy Program, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104; wilsonjm@upenn.edu.

Proc Natl Acad Sci U S A ; 114(7): 1655-1659, 2017 02 14.

Article em En | MEDLINE | ID: mdl-28137880

Assuntos

Terapia Genética/métodos; Peptídeos/imunologia; Linfócitos T/imunologia; Deficiência de alfa 1-Antitripsina/terapia; alfa 1-Antitripsina/imunologia; Adulto; Idoso; Alelos; Sequência de Aminoácidos; Dependovirus/genética; Feminino; Antígenos HLA/genética; Antígenos HLA/imunologia; Humanos; Células K562; Masculino; Pessoa de Meia-Idade; Peptídeos/genética; Peptídeos/metabolismo; Polimorfismo Genético; Linfócitos T/metabolismo; alfa 1-Antitripsina/genética; alfa 1-Antitripsina/metabolismo; Deficiência de alfa 1-Antitripsina/genética; Deficiência de alfa 1-Antitripsina/imunologia

Palavras-chave

a-1-antitrypsin; adeno-associated virus; gene therapy; immune response; polymorphism

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Linfócitos T / Terapia Genética / Alfa 1-Antitripsina / Deficiência de alfa 1-Antitripsina Tipo de estudo: Clinical_trials Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2017 Tipo de documento: Article

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