Investigation of the role of environmental contamination in the occurrence of residues of the veterinary drug phenylbutazone in cattle.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess
; 34(4): 520-524, 2017 Apr.
Article
em En
| MEDLINE
| ID: mdl-28140763
ABSTRACT
Phenylbutazone is a non-steroidal anti-inflammatory drug licensed for use in horses to treat musculoskeletal disorders. It is not permitted in the European Union for use in animals destined for the food chain. Official statistics provided by the European Food Safety Authority (EFSA) show that 0.18% of bovines tested in the European Union between 2008 and 2014 for non-steroidal anti-inflammatory drugs were non-compliant, with phenylbutazone representing over 28% of these. Anecdotal evidence suggests animals that have not been treated with the drug may have produced non-compliant samples, possibly through some form of contamination. In this study, ultra-high-performance liquid chromatography coupled with mass-spectrometric detection was applied to bovine plasma samples to determine if detectable residues (CCα = 0.28 ng ml-1) may occur in untreated animals as a result of environmental contamination through normal farming practice. The study demonstrates that waste from animals treated with phenylbutazone, and spread on an area of pasture, can contaminate untreated bovines grazing the pasture many weeks later. It was determined that this contamination, which can persist over a significant period, may be due to the ingestion of as little as 30 µg phenylbutazone by a 500 kg bullock.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Resíduos de Drogas
/
Fenilbutazona
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Anti-Inflamatórios não Esteroides
/
Drogas Veterinárias
/
Poluição Ambiental
Aspecto:
Determinantes_sociais_saude
Limite:
Animals
País/Região como assunto:
Europa
Idioma:
En
Revista:
Food Addit Contam Part A Chem Anal Control Expo Risk Assess
Ano de publicação:
2017
Tipo de documento:
Article