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Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.
Law, Philip J; Berndt, Sonja I; Speedy, Helen E; Camp, Nicola J; Sava, Georgina P; Skibola, Christine F; Holroyd, Amy; Joseph, Vijai; Sunter, Nicola J; Nieters, Alexandra; Bea, Silvia; Monnereau, Alain; Martin-Garcia, David; Goldin, Lynn R; Clot, Guillem; Teras, Lauren R; Quintela, Inés; Birmann, Brenda M; Jayne, Sandrine; Cozen, Wendy; Majid, Aneela; Smedby, Karin E; Lan, Qing; Dearden, Claire; Brooks-Wilson, Angela R; Hall, Andrew G; Purdue, Mark P; Mainou-Fowler, Tryfonia; Vajdic, Claire M; Jackson, Graham H; Cocco, Pierluigi; Marr, Helen; Zhang, Yawei; Zheng, Tongzhang; Giles, Graham G; Lawrence, Charles; Call, Timothy G; Liebow, Mark; Melbye, Mads; Glimelius, Bengt; Mansouri, Larry; Glenn, Martha; Curtin, Karen; Diver, W Ryan; Link, Brian K; Conde, Lucia; Bracci, Paige M; Holly, Elizabeth A; Jackson, Rebecca D; Tinker, Lesley F.
Afiliação
  • Law PJ; Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.
  • Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
  • Speedy HE; Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.
  • Camp NJ; Department of Internal Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.
  • Sava GP; Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.
  • Skibola CF; Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.
  • Holroyd A; Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.
  • Joseph V; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
  • Sunter NJ; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Nieters A; Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Baden-Württemberg 79108, Germany.
  • Bea S; Institut d'Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Hospital Clínic, Barcelona 08036, Spain.
  • Monnereau A; Registre des hémopathies malignes de la Gironde, Institut Bergonié, Inserm U1219 EPICENE, 33076 Bordeaux, France.
  • Martin-Garcia D; Epidemiology of Childhood and Adolescent Cancers Group, Inserm, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité, Paris, F-94807, France.
  • Goldin LR; Université Paris Descartes, Paris 75270, France.
  • Clot G; Institut d'Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Hospital Clínic, Barcelona 08036, Spain.
  • Teras LR; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
  • Quintela I; Institut d'Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Hospital Clínic, Barcelona 08036, Spain.
  • Birmann BM; Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30303, USA.
  • Jayne S; Grupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado (CeGen-PRB2-ISCIII), CIBERER, 15782 Santiago de Compostela, Spain.
  • Cozen W; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Majid A; Ernest and Helen Scott Haematological Research Institute, University of Leicester, Leicester LE2 7LX, UK.
  • Smedby KE; Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.
  • Lan Q; Norris Comprehensive Cancer Center, USC Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.
  • Dearden C; Ernest and Helen Scott Haematological Research Institute, University of Leicester, Leicester LE2 7LX, UK.
  • Brooks-Wilson AR; Unit of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Hematology Center, Karolinsak University Hospital, Stockholm 17176, Sweden.
  • Hall AG; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
  • Purdue MP; The Royal Marsden NHS Foundation Trust, London SM2 5PT, UK.
  • Mainou-Fowler T; Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z1L3.
  • Vajdic CM; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia V5A1S6, Canada.
  • Jackson GH; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Cocco P; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
  • Marr H; Haematological Sciences, Medical School, Newcastle University, Newcastle-upon-Tyne NE2 4HH, UK.
  • Zhang Y; Centre for Big Data Research in Health, University of New South Wales, Sydney, New South Wales 2052, Australia.
  • Zheng T; Department of Haematology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK.
  • Giles GG; Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Monserrato, Cagliari 09042, Italy.
  • Lawrence C; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Call TG; Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06520, USA.
  • Liebow M; Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06520, USA.
  • Melbye M; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.
  • Glimelius B; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria 3010, Australia.
  • Mansouri L; Westat, Rockville, Maryland 20850, USA.
  • Glenn M; Division of Hematology, Mayo Clinic, Rochester, Minnesota 55905, USA.
  • Curtin K; Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
  • Diver WR; Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, 2300 Copenhagen, Denmark.
  • Link BK; Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.
  • Conde L; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 75105 Uppsala, Sweden.
  • Bracci PM; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 75105 Uppsala, Sweden.
  • Holly EA; Department of Internal Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.
  • Jackson RD; Department of Internal Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.
  • Tinker LF; Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30303, USA.
Nat Commun ; 8: 14175, 2017 02 06.
Article em En | MEDLINE | ID: mdl-28165464
ABSTRACT
Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1,000 Genomes and UK10K data, totalling 6,200 cases and 17,598 controls after replication. We identify nine risk loci at 1p36.11 (rs34676223, P=5.04 × 10-13), 1q42.13 (rs41271473, P=1.06 × 10-10), 4q24 (rs71597109, P=1.37 × 10-10), 4q35.1 (rs57214277, P=3.69 × 10-8), 6p21.31 (rs3800461, P=1.97 × 10-8), 11q23.2 (rs61904987, P=2.64 × 10-11), 18q21.1 (rs1036935, P=3.27 × 10-8), 19p13.3 (rs7254272, P=4.67 × 10-8) and 22q13.33 (rs140522, P=2.70 × 10-9). These new and established risk loci map to areas of active chromatin and show an over-representation of transcription factor binding for the key determinants of B-cell development and immune response.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Linfocítica Crônica de Células B / Cromossomos Humanos / Predisposição Genética para Doença / Formação de Anticorpos Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Linfocítica Crônica de Células B / Cromossomos Humanos / Predisposição Genética para Doença / Formação de Anticorpos Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Ano de publicação: 2017 Tipo de documento: Article