Effect of neostigmine on contractility of equine pre-ovulatory follicles: An in vitro study.

ABSTRACT

In this study, the Authors investigated the modulatory effect of three single doses (10-6, 10-5, and 10-4 M) of neostigmine on the spontaneous contractility of equine pre-ovulatory follicles in an isolated organ bath, to establish the relationship between this acetylcholinesterase inhibitor and ovulation, in the mare. The results indicate that neostigmine increases pre-ovulatory contractility in equine follicles at each dose, but in a different manner. Indeed, the rise in contractility induced by neostigmine at 10-6 M and 10-4 M was phasic, while at 10-5 M it was tonic. The data obtained indicate possible implications of these drugs in the pharmacological modulation of equine ovulation.