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Protein-Induced Pluripotent Stem Cells Ameliorate Cognitive Dysfunction and Reduce Aß Deposition in a Mouse Model of Alzheimer's Disease.
Cha, Moon-Yong; Kwon, Yoo-Wook; Ahn, Hyo-Suk; Jeong, Hyobin; Lee, Yong Yook; Moon, Minho; Baik, Sung Hoon; Kim, Dong Kyu; Song, Hyundong; Yi, Eugene C; Hwang, Daehee; Kim, Hyo-Soo; Mook-Jung, Inhee.
Afiliação
  • Cha MY; Department of Biochemistry and Biomedical Sciences, Seoul National University, Seoul, Republic of Korea.
  • Kwon YW; Innovative Research Institute for Cell Therapy, Seoul National University Hospital, Seoul, Republic of Korea.
  • Ahn HS; National Research Laboratory for Stem Cell Niche, Seoul National University, Seoul, Republic of Korea.
  • Jeong H; Department of New Biology and Center for Plant and Aging Research, Institute for Basic Science, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea.
  • Lee YY; The Korean Ginseng Research Institute, Daejeon, Republic of Korea.
  • Moon M; Department of Biochemistry, College of Medicine, Konyang University, Daejeon, Republic of Korea.
  • Baik SH; Department of Biochemistry and Biomedical Sciences, Seoul National University, Seoul, Republic of Korea.
  • Kim DK; Department of Biochemistry and Biomedical Sciences, Seoul National University, Seoul, Republic of Korea.
  • Song H; Department of Biochemistry and Biomedical Sciences, Seoul National University, Seoul, Republic of Korea.
  • Yi EC; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, School of Medicine and School of Pharmacy, Seoul National University, Seoul, Republic of Korea.
  • Hwang D; Department of New Biology and Center for Plant and Aging Research, Institute for Basic Science, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea.
  • Kim HS; Innovative Research Institute for Cell Therapy, Seoul National University Hospital, Seoul, Republic of Korea.
  • Mook-Jung I; National Research Laboratory for Stem Cell Niche, Seoul National University, Seoul, Republic of Korea.
Stem Cells Transl Med ; 6(1): 293-305, 2017 01.
Article em En | MEDLINE | ID: mdl-28170178
ABSTRACT
Transplantation of stem cells into the brain attenuates functional deficits in the central nervous system via cell replacement, the release of specific neurotransmitters, and the production of neurotrophic factors. To identify patient-specific and safe stem cells for treating Alzheimer's disease (AD), we generated induced pluripotent stem cells (iPSCs) derived from mouse skin fibroblasts by treating protein extracts of embryonic stem cells. These reprogrammed cells were pluripotent but nontumorigenic. Here, we report that protein-iPSCs differentiated into glial cells and decreased plaque depositions in the 5XFAD transgenic AD mouse model. We also found that transplanted protein-iPSCs mitigated the cognitive dysfunction observed in these mice. Proteomic analysis revealed that oligodendrocyte-related genes were upregulated in brains injected with protein-iPSCs, providing new insights into the potential function of protein-iPSCs. Taken together, our data indicate that protein-iPSCs might be a promising therapeutic approach for AD. Stem Cells Translational Medicine 2017;6293-305.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Assunto principal: Peptídeos beta-Amiloides / Células-Tronco Pluripotentes Induzidas / Doença de Alzheimer / Disfunção Cognitiva Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Stem Cells Transl Med Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Assunto principal: Peptídeos beta-Amiloides / Células-Tronco Pluripotentes Induzidas / Doença de Alzheimer / Disfunção Cognitiva Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Stem Cells Transl Med Ano de publicação: 2017 Tipo de documento: Article