Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C<sub>1</sub>C<sub>2</sub>BMUN.

Xu, Junjie; Camacho, Marcial; Xu, Yibin; Esser, Victoria; Liu, Xiaoxia; Trimbuch, Thorsten; Pan, Yun-Zu; Ma, Cong; Tomchick, Diana R; Rosenmund, Christian; Rizo, Josep

Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C₁C₂BMUN.

Xu, Junjie; Camacho, Marcial; Xu, Yibin; Esser, Victoria; Liu, Xiaoxia; Trimbuch, Thorsten; Pan, Yun-Zu; Ma, Cong; Tomchick, Diana R; Rosenmund, Christian; Rizo, Josep.

Afiliação

Xu J; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States.
Camacho M; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, United States.
Xu Y; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States.
Esser V; Department of Neurophysiology, NeuroCure Cluster of Excellence, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Liu X; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States.
Trimbuch T; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, United States.
Pan YZ; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States.
Ma C; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States.
Tomchick DR; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, United States.
Rosenmund C; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States.
Rizo J; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States.

Elife ; 62017 02 08.

Article em En | MEDLINE | ID: mdl-28177287

Assuntos

Proteínas do Tecido Nervoso/química; Proteínas do Tecido Nervoso/metabolismo; Neurotransmissores/metabolismo; Animais; Células Cultivadas; Cristalografia por Raios X; Camundongos; Modelos Moleculares; Neurônios/fisiologia; Conformação Proteica; Ratos

Palavras-chave

Munc13; biophysics; calcium binding; mouse; neuroscience; neurotransmitter release; presynaptic plasticity; structural biology; synaptic vesicle fusion

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neurotransmissores / Proteínas do Tecido Nervoso Limite: Animals Idioma: En Revista: Elife Ano de publicação: 2017 Tipo de documento: Article

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