Towards Selective Mycobacterial ClpP1P2 Inhibitors with Reduced Activity against the Human Proteasome.

Moreira, Wilfried; Santhanakrishnan, Sridhar; Ngan, Grace J Y; Low, Choon Bing; Sangthongpitag, Kanda; Poulsen, Anders; Dymock, Brian W; Dick, Thomas

Moreira, Wilfried; Santhanakrishnan, Sridhar; Ngan, Grace J Y; Low, Choon Bing; Sangthongpitag, Kanda; Poulsen, Anders; Dymock, Brian W; Dick, Thomas.

Afiliação

Moreira W; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Santhanakrishnan S; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Ngan GJY; Department of Pharmacy, National University of Singapore, Singapore.
Low CB; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Sangthongpitag K; Experimental Therapeutics Center, Agency for Science, Technology and Research (A*STAR), Singapore.
Poulsen A; Experimental Therapeutics Center, Agency for Science, Technology and Research (A*STAR), Singapore.
Dymock BW; Experimental Therapeutics Center, Agency for Science, Technology and Research (A*STAR), Singapore.
Dick T; Department of Chemistry, National University of Singapore, Singapore.

Antimicrob Agents Chemother ; 61(5)2017 05.

Article em En | MEDLINE | ID: mdl-28193668

Assuntos

Antibacterianos/farmacologia; Proteínas de Bactérias/antagonistas & inibidores; Bortezomib/farmacologia; Endopeptidase Clp/antagonistas & inibidores; Mycobacterium smegmatis/efeitos dos fármacos; Mycobacterium tuberculosis/efeitos dos fármacos; Inibidores de Proteassoma/farmacologia; Animais; Proteínas de Bactérias/genética; Bortezomib/farmacocinética; Desenho de Fármacos; Endopeptidase Clp/genética; Camundongos; Testes de Sensibilidade Microbiana; Modelos Moleculares; Mycobacterium smegmatis/genética; Serina Endopeptidases/genética; Tuberculose Pulmonar/tratamento farmacológico; Tuberculose Pulmonar/microbiologia

Palavras-chave

antimycobacterial; caseinolytic protease; dipeptidyl boronic acid

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Mycobacterium smegmatis / Endopeptidase Clp / Inibidores de Proteassoma / Bortezomib / Antibacterianos / Mycobacterium tuberculosis Limite: Animals Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2017 Tipo de documento: Article

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