Down-regulation of PE11, a cell wall associated esterase, enhances the biofilm growth of Mycobacterium tuberculosis and reduces cell wall virulence lipid levels.

Rastogi, Shivangi; Singh, Amit Kumar; Pant, Garima; Mitra, Kalyan; Sashidhara, Koneni V; Krishnan, Manju Y

Rastogi, Shivangi; Singh, Amit Kumar; Pant, Garima; Mitra, Kalyan; Sashidhara, Koneni V; Krishnan, Manju Y.

Afiliação

Rastogi S; Division of Microbiology, Council of Scientific and Industrial Research, Central Drug Research Institute, Sitapur Road, Lucknow, Uttar Pradesh 226 031, India.
Singh AK; Division of Molecular and Structural Biology, Council of Scientific and Industrial Research, Central Drug Research Institute, Sitapur Road, Lucknow, Uttar Pradesh 226 031, India.
Pant G; Sophisticated Analytical Instrument Facility, Council of Scientific and Industrial Research, Central Drug Research Institute, Sitapur Road, Lucknow, Uttar Pradesh 226 031, India.
Mitra K; Sophisticated Analytical Instrument Facility, Council of Scientific and Industrial Research, Central Drug Research Institute, Sitapur Road, Lucknow, Uttar Pradesh 226 031, India.
Sashidhara KV; Medicinal and Process Chemistry Division, Council of Scientific and Industrial Research, Central Drug Research Institute, Sitapur Road, Lucknow, Uttar Pradesh 226 031, India.
Krishnan MY; Division of Microbiology, Council of Scientific and Industrial Research, Central Drug Research Institute, Sitapur Road, Lucknow, Uttar Pradesh 226 031, India.

Microbiology (Reading) ; 163(1): 52-61, 2017 01.

Article em En | MEDLINE | ID: mdl-28198348

Assuntos

Proteínas de Bactérias/biossíntese; Biofilmes/crescimento & desenvolvimento; Parede Celular/metabolismo; Esterases/biossíntese; Lipídeos de Membrana/metabolismo; Mycobacterium tuberculosis/crescimento & desenvolvimento; Mycobacterium tuberculosis/patogenicidade; Proteínas de Bactérias/genética; Linhagem Celular; Esterases/genética; Fibronectinas/metabolismo; Técnicas de Inativação de Genes; Humanos; Lipídeos/biossíntese; Macrófagos/microbiologia; Mycobacterium smegmatis/genética; Mycobacterium smegmatis/patogenicidade; Mycobacterium tuberculosis/genética; Ácidos Micólicos/metabolismo; Acetato de Tetradecanoilforbol/farmacologia; Trealose/metabolismo; Fatores de Virulência/metabolismo

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 / 3_ND Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Parede Celular / Biofilmes / Esterases / Lipídeos de Membrana / Mycobacterium tuberculosis Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Microbiology (Reading) Ano de publicação: 2017 Tipo de documento: Article

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